Thörnqvist Victoria, Middelveld Roelinde, Wai Hay Mar, Ballardini Natalia, Nilsson Evalill, Strömquist Jennie, Ahlstedt Staffan, Nilsson Lennart Jan, Protudjer Jennifer L P
1The Centre for Allergy Research, Karolinska Institutet, Box 210, 171 77 Stockholm, Sweden.
2The Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Clin Transl Allergy. 2019 Feb 7;9:10. doi: 10.1186/s13601-019-0244-0. eCollection 2019.
Food allergy is negatively associated with health-related quality of life (HRQL). Although differences exist between parents and children, less is known about age-specific differences amongst children. As such, we aimed to identify if age, as well as other factors, are associated with food allergy-specific HRQL in an objectively defined population of children.
Overall, 63 children (boys: n = 36; 57.1%) with specialist-diagnosed food allergy to 1 + foods were included. Parents/guardians completed the Swedish version of a disease-specific questionnaire designed to assess overall- and domain-specific HRQL. Descriptive statistics and linear regression were used.
The most common food allergy was hen's egg (n = 40/63; 63.5%). Most children had more than one food allergy (n = 48; 76.2%). Nearly all had experienced mild symptoms (e.g. skin; n = 56/63; 94.9%), and more than half had severe symptoms (e.g. respiratory; 39/63; 66.1%). Compared to young children (0-5 years), older children (6-12 years) had worse HRQL (e.g. overall HRQL: B = 0.60; 95% CI 0.05-1.16; < 0.04.). Similarly, multiple food allergies, and severe symptoms were significantly associated with worse HRQL (all < 0.05) even in models adjusted for concomitant allergic disease. No associations were found for gender or socioeconomic status.
Older children and those with severe food allergy have worse HRQL.
食物过敏与健康相关生活质量（HRQL）呈负相关。尽管父母与儿童之间存在差异，但对于儿童中特定年龄的差异了解较少。因此，我们旨在确定年龄以及其他因素是否与客观定义的儿童群体中食物过敏特异性HRQL相关。
总共纳入了63名经专科诊断对1种以上食物过敏的儿童（男孩：n = 36；57.1%）。父母/监护人完成了一份瑞典语版的特定疾病问卷，该问卷旨在评估总体和特定领域的HRQL。使用了描述性统计和线性回归。
最常见的食物过敏是鸡蛋（n = 40/63；63.5%）。大多数儿童有不止一种食物过敏（n = 48；76.2%）。几乎所有儿童都经历过轻度症状（如皮肤症状；n = 56/63；94.9%），超过一半的儿童有严重症状（如呼吸道症状；39/63；66.1%）。与年幼儿童（0 - 5岁）相比，年长儿童（6 - 12岁）HRQL更差（如总体HRQL：B = 0.60；95% CI 0.05 - 1.16；P < 0.04）。同样，即使在针对伴随过敏性疾病进行调整的模型中，多种食物过敏和严重症状也与更差的HRQL显著相关（所有P < 0.05）。未发现性别或社会经济地位与HRQL有关联。
年长儿童和患有严重食物过敏的儿童HRQL更差。
