Stark Christian, Behroozian Reza, Redmer Benjamin, Fiedler Felix, Müller Stefan
Lübeck University of Applied Sciences, Medical Sensors and Devices Laboratory, Mönkhofer Weg 239, Lübeck 23562, Germany.
University of Lübeck, Graduate School for Computing in Medicine and Life Sciences, Ratzeburger Allee 160, Lübeck 23562, Germany.
Biomed Opt Express. 2018 Dec 19;10(1):308-321. doi: 10.1364/BOE.10.000308. eCollection 2019 Jan 1.
Polarimetric determination of glucose is known to be strongly affected by scattering in turbid media. Other effects like fluctuations of light source emission and sample absorption also deteriorate glucose predictability. This work presents a measurement setup using a real-time data processing method to address these problems. The approach uses the frequency-dependent intensity components created when the polarization of the incident light is periodically modulated by a Faraday rotator. The efficacy of the proposed method was verified experimentally for a glucose range of 0 - 500 mg/dl. It was shown that the approach reduces the prediction errors in slightly turbid media from 35.7 mg/dl down to 1.17 mg/dl. In a similar way, the glucose predictability for fluctuating light source emission was improved from ±16.16 mg/dl to ±1 mg/dl and for varying sample absorbance from ±15.69 mg/dl to ±1.23 mg/dl, respectively. Therefore, considerable improvement of robustness and reproducibility of glucose determination was demonstrated.
已知在浑浊介质中，葡萄糖的偏振测定会受到散射的强烈影响。其他影响，如光源发射的波动和样品吸收，也会降低葡萄糖的可预测性。这项工作提出了一种使用实时数据处理方法的测量装置来解决这些问题。该方法利用了当入射光的偏振由法拉第旋转器周期性调制时产生的频率相关强度分量。所提出方法的有效性在0 - 500 mg/dl的葡萄糖范围内通过实验得到了验证。结果表明，该方法将微浑浊介质中的预测误差从35.7 mg/dl降低到了1.17 mg/dl。同样地，对于波动的光源发射，葡萄糖的可预测性从±16.16 mg/dl提高到了±1 mg/dl，对于变化的样品吸光度，从±15.69 mg/dl分别提高到了±1.23 mg/dl。因此，证明了葡萄糖测定的稳健性和可重复性有了显著提高。
