Luo Fei, Wang Yu-Zhuo, Lin Dong, Li Jian, Yang Kuo
Department of Urology, Tianjin Union Medical Center, Tianjin, China.
The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, British Columbia, Canada.
J Cell Biochem. 2019 Jul;120(7):11383-11389. doi: 10.1002/jcb.28415. Epub 2019 Feb 18.
Prostate cancer (PCa) is the most prevalent malignancy and the second leading cause of cancer-related deaths in the male population in western countries, and we explored the association between exonuclease 1 (EXO1) expression and clinical progression, metastasis (Met), and survival prognosis of PCa. EXO1 expression of high/low-metastatic patient-derived xenografts model was investigated and clinical correlation and prognosis outcomes were validated. EXO1 in high-metastatic models was significantly increased compared with low-metastatic lines. In memorial sloan-kettering cancer center (MSKCC) cohort, EXO1 expression positively correlated with PCa Met, and patients with high EXO1 had poor biochemical recurrence-free survival in primary PCa cohort. Validation in The Cancer Genome Atlas primary cohort indicated EXO1 expression was significantly associated with lymph node Met and disease-free survival. The overexpression of EXO1 is significantly associated with PCa poor survival outcome, and is a promising biomarker for PCa, especially for primary PCa. A prospective study is clearly needed to validate these findings.
前列腺癌（PCa）是西方国家男性人群中最常见的恶性肿瘤，也是癌症相关死亡的第二大主要原因，我们探讨了核酸外切酶1（EXO1）表达与PCa临床进展、转移（Met）及生存预后之间的关联。研究了高/低转移患者来源的异种移植模型中EXO1的表达情况，并验证了其临床相关性和预后结果。与低转移系相比，高转移模型中的EXO1显著增加。在纪念斯隆凯特琳癌症中心（MSKCC）队列中，EXO1表达与PCa转移呈正相关，在原发性PCa队列中，EXO1水平高的患者无生化复发生存期较差。癌症基因组图谱原发性队列中的验证表明，EXO1表达与淋巴结转移和无病生存期显著相关。EXO1的过表达与PCa不良生存结果显著相关，是PCa，尤其是原发性PCa的一个有前景的生物标志物。显然需要进行一项前瞻性研究来验证这些发现。
