State Key Laboratory of Remote Sensing Science, College of Global Change and Earth System Science, Beijing Normal University, Beijing, China.
Centre for Ecological and Evolutionary Synthesis (CEES), Department of Biosciences, University of Oslo, Blindern, Oslo, Norway.
PLoS Negl Trop Dis. 2019 Feb 21;13(2):e0006901. doi: 10.1371/journal.pntd.0006901. eCollection 2019 Feb.
Hantaviruses can cause hantavirus pulmonary syndrome (HPS) in the Americas and hemorrhagic fever with renal syndrome (HFRS) in Eurasia. In recent decades, repeated outbreaks of hantavirus disease have led to public concern and have created a global public health burden. Hantavirus spillover from natural hosts into human populations could be considered an ecological process, in which environmental forces, behavioral determinants of exposure, and dynamics at the human-animal interface affect human susceptibility and the epidemiology of the disease. In this review, we summarize the progress made in understanding hantavirus epidemiology and rodent reservoir population biology. We mainly focus on three species of rodent hosts with longitudinal studies of sufficient scale: the striped field mouse (Apodemus agrarius, the main reservoir host for Hantaan virus [HTNV], which causes HFRS) in Asia, the deer mouse (Peromyscus maniculatus, the main reservoir host for Sin Nombre virus [SNV], which causes HPS) in North America, and the bank vole (Myodes glareolus, the main reservoir host for Puumala virus [PUUV], which causes HFRS) in Europe. Moreover, we discuss the influence of ecological factors on human hantavirus disease outbreaks and provide an overview of research perspectives.
汉坦病毒可引起美洲的汉坦病毒肺综合征（HPS）和欧亚大陆的肾综合征出血热（HFRS）。近几十年来，汉坦病毒病的反复爆发引起了公众的关注，并给全球公共卫生带来了负担。汉坦病毒从自然宿主溢出到人群中可被视为一种生态过程，其中环境力量、暴露的行为决定因素以及人类与动物接触界面的动态会影响人类易感性和疾病的流行病学。在这篇综述中，我们总结了在理解汉坦病毒流行病学和啮齿动物储存宿主种群生物学方面取得的进展。我们主要关注三种具有足够规模的纵向研究的啮齿动物宿主：亚洲的黑线姬鼠（Apodemus agrarius，汉坦病毒[HTNV]的主要储存宿主，引起 HFRS）、北美洲的鹿鼠（Peromyscus maniculatus，辛诺柏病毒[SNV]的主要储存宿主，引起 HPS）和欧洲的田鼠（Myodes glareolus，普马拉病毒[PUUV]的主要储存宿主，引起 HFRS）。此外，我们还讨论了生态因素对人类汉坦病毒病爆发的影响，并提供了研究展望。
