Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.
Department of Rheumatology, Máxima Medisch Centrum, Eindhoven, The Netherlands.
PLoS One. 2019 Feb 22;14(2):e0209761. doi: 10.1371/journal.pone.0209761. eCollection 2019.
To determine whether optical spectral transmission (OST) can be used to assess synovitis in hand and wrist joints of patients with hand osteoarthritis (OA).
Hand and wrist joints of 47 primary hand OA patients with at least one clinically inflamed hand or wrist joint were assessed for synovitis by OST and ultrasound (US). Associations between standardized OST and US synovitis were studied in linear mixed effects models, across all joint types together and individually for wrist, proximal interphalangeal (PIP), and distal interphalangeal (DIP) joints, and were adjusted for OA features that showed associations with US synovitis. Diagnostic performance was determined using receiver operator characteristic (ROC) curves analysis, with US as reference standard.
Altogether, 6.7% of joints showed US synovitis. Statistically significant associations between OST scores and US synovitis were found for all joints combined (Δ0.37SD, p<0.001) and PIP joints (Δ0.81SD, p<0.001), but not for DIP (Δ0.14SD, p = 0.484) or wrist joints (Δ0.37SD, p = 0.178). All associations were independent of other OA features, i.e. osteophytes and dorsal vascularity. Analysis of diagnostic performance of OST, revealed an area under the ROC curve (AUC-ROC) of 0.74 for all joints together (p<0.001), 0.69 for PIP joints (p<0.001), 0.54 for DIP joints (p = 0.486), and 0.61 for wrist joints (p = 0.234).
OST scores and US synovitis are statistically significantly associated, independent of osteophytes and dorsal vascularity. At this stage, OST performs fair in the assessment of synovitis in PIP joints of hand OA patients.
确定光学光谱透射（OST）是否可用于评估手骨关节炎（OA）患者手部和腕关节的滑膜炎。
对 47 例原发性手部 OA 患者的手部和腕关节进行 OST 和超声（US）评估，以确定滑膜炎。在所有关节类型中，以及单独对腕关节、近端指间关节（PIP）和远端指间关节（DIP）进行线性混合效应模型研究，标准化 OST 与 US 滑膜炎之间的相关性，并对与 US 滑膜炎相关的 OA 特征进行调整。使用接收者操作特征（ROC）曲线分析确定诊断性能，以 US 作为参考标准。
总共，6.7%的关节出现 US 滑膜炎。OST 评分与 US 滑膜炎之间存在统计学显著相关性，所有关节（Δ0.37SD，p<0.001）和 PIP 关节（Δ0.81SD，p<0.001），但 DIP（Δ0.14SD，p = 0.484）或腕关节（Δ0.37SD，p = 0.178）没有。所有关联均独立于其他 OA 特征，即骨赘和背侧血管性。OST 分析诊断性能，显示 ROC 曲线下面积（AUC-ROC）为 0.74（p<0.001），PIP 关节为 0.69（p<0.001），DIP 关节为 0.54（p = 0.486），腕关节为 0.61（p = 0.234）。
OST 评分与 US 滑膜炎具有统计学显著相关性，与骨赘和背侧血管性无关。在现阶段，OST 在评估手部 OA 患者 PIP 关节滑膜炎方面表现良好。
