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自由基对介导的 50/60 Hz 磁场生物效应的上限。

Upper bound on the biological effects of 50/60 Hz magnetic fields mediated by radical pairs.

机构信息

Department of Chemistry, Physical & Theoretical Chemistry Laboratory, University of Oxford, Oxford, United Kingdom.

出版信息

Elife. 2019 Feb 25;8:e44179. doi: 10.7554/eLife.44179.

DOI:10.7554/eLife.44179
PMID:30801245
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6417859/
Abstract

Prolonged exposure to weak (~1 μT) extremely-low-frequency (ELF, 50/60 Hz) magnetic fields has been associated with an increased risk of childhood leukaemia. One of the few biophysical mechanisms that might account for this link involves short-lived chemical reaction intermediates known as radical pairs. In this report, we use spin dynamics simulations to derive an upper bound of 10 parts per million on the effect of a 1 μT ELF magnetic field on the yield of a radical pair reaction. By comparing this figure with the corresponding effects of changes in the strength of the Earth's magnetic field, we conclude that if exposure to such weak 50/60 Hz magnetic fields has any effect on human biology, and results from a radical pair mechanism, then the risk should be no greater than travelling a few kilometres towards or away from the geomagnetic north or south pole.

摘要

长时间暴露于弱(约 1 μT)极低频(ELF,50/60 Hz)磁场与儿童白血病风险增加有关。少数可能解释这种联系的生物物理机制之一涉及称为自由基对的短寿命化学反应中间体。在本报告中,我们使用自旋动力学模拟得出了 1 μT ELF 磁场对自由基对反应产率影响的上限为 10 ppm。通过将该数字与地球磁场强度变化的相应影响进行比较,我们得出结论,如果暴露于这种弱的 50/60 Hz 磁场对人类生物学有任何影响,并且是自由基对机制的结果,那么这种风险不应大于朝向或远离地磁北极或南极旅行几公里。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eff7/6417859/39accf7ac01f/elife-44179-fig4-figsupp3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eff7/6417859/237f7540ebeb/elife-44179-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eff7/6417859/5505db25d01f/elife-44179-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eff7/6417859/fc93f2d89cbb/elife-44179-fig2-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eff7/6417859/93f6c0c92cde/elife-44179-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eff7/6417859/955a52189143/elife-44179-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eff7/6417859/8f33a1ea6d23/elife-44179-fig4-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eff7/6417859/adec2f5eb386/elife-44179-fig4-figsupp2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eff7/6417859/39accf7ac01f/elife-44179-fig4-figsupp3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eff7/6417859/237f7540ebeb/elife-44179-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eff7/6417859/5505db25d01f/elife-44179-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eff7/6417859/fc93f2d89cbb/elife-44179-fig2-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eff7/6417859/93f6c0c92cde/elife-44179-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eff7/6417859/955a52189143/elife-44179-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eff7/6417859/8f33a1ea6d23/elife-44179-fig4-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eff7/6417859/adec2f5eb386/elife-44179-fig4-figsupp2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eff7/6417859/39accf7ac01f/elife-44179-fig4-figsupp3.jpg

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