Mental Health Epidemiology and Treatment Services Program, RTI International, Research Triangle Park, North Carolina, USA.
Department of Psychology, North Carolina State University, Raleigh, North Carolina, USA.
Int J Methods Psychiatr Res. 2019 Sep;28(3):e1776. doi: 10.1002/mpr.1776. Epub 2019 Feb 27.
Methodological limitations of extant research hinder the development of effective violence risk screening, assessment, and management strategies for adults with mental illness. This study quantifies the effects of three common limitations: (a) insensitive measurement of violence that results in violence classification with high levels of information bias, (b) use of cross-sectional data, and (c) use of data lacking spatiotemporal contiguity.
We utilize secondary data (N = 3,000 participants; N = 10,017 observations) and parametric and nonparametric bootstrap simulation methodologies.
Not utilizing self-reported violence data increases information bias. Furthermore, cross-sectional data that exclude self-reported violence produce biased associations between substance use and psychiatric symptoms and violence. Associations between baseline variables and subsequent violence attenuate over longer time lags and, when paired with high levels of violence information bias, result in fewer significant effects than should be present. Moreover, the true direction of the simulated relationship of some significant effects is reversed.
Our findings suggest that the validity of conclusions from some extant research on violence among adults with mental illness should be questioned. Efforts are needed to improve both the measurement of violence, through inclusion of self-report, and the statistical modeling of violence, using lagged rather than nonlagged models with improved spatiotemporal contiguity.
现有研究方法学上的局限性阻碍了为精神疾病成年患者制定有效暴力风险筛查、评估和管理策略的发展。本研究量化了三种常见局限性的影响:(a)暴力测量不敏感,导致暴力分类存在高水平的信息偏倚;(b)使用横断面数据;(c)使用缺乏时空连续性的数据。
我们利用二次数据(N=3000 名参与者;N=10017 次观察)和参数与非参数自举模拟方法。
不使用自我报告的暴力数据会增加信息偏倚。此外,排除自我报告暴力的横断面数据会导致物质使用和精神症状与暴力之间存在有偏关联。基线变量与随后的暴力之间的关联随着时间滞后的延长而减弱,并且当与高水平的暴力信息偏倚相结合时,会导致比实际存在的更少的显著效应。此外,一些显著效应的模拟关系的真实方向被反转。
我们的研究结果表明,一些关于精神疾病成年患者暴力的现有研究的结论的有效性应受到质疑。需要努力改进暴力的测量,通过包括自我报告,以及通过使用具有改进时空连续性的滞后而不是非滞后模型来改进暴力的统计建模。