肠道微生态在膳食多酚及其代谢产物对能量代谢的调节中的作用。
Role of intestinal microecology in the regulation of energy metabolism by dietary polyphenols and their metabolites.
作者信息
Lin Shaoling, Wang Zhengyu, Lam Ka-Lung, Zeng Shaoxiao, Tan Bee K, Hu Jiamiao
机构信息
College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, China.
School of Life Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.
出版信息
Food Nutr Res. 2019 Feb 14;63. doi: 10.29219/fnr.v63.1518. eCollection 2019.
BACKGROUND
Polyphenols are a class of plant secondary metabolites with a variety of physiological functions. Polyphenols and their intestinal metabolites could greatly affect host energy metabolism via multiple mechanisms.
OBJECTIVE
The objective of this review was to elaborate the role of intestinal microecology in the regulatory effects of dietary polyphenols and their metabolites on energy metabolism.
METHODS
In this review, we illustrated the potential mechanisms of energy metabolism regulated by the crosstalk between polyphenols and intestinal microecology including intestinal microbiota, intestinal epithelial cells, and mucosal immune system.
RESULTS
Polyphenols can selectively regulate the growth of susceptible microorganisms (eg. reducing the ratio of Firmicutes to Bacteroides, promoting the growth of beneficial bacteria and inhibiting pathogenic bacteria) as well as alter bacterial enzyme activity. Moreover, polyphenols can influence the absorption and secretion of intestinal epithelial cells, and alter the intestinal mucosal immune system.
CONCLUSION
The intestinal microecology play a crucial role for the regulation of energy metabolism by dietary polyphenols.
背景
多酚是一类具有多种生理功能的植物次生代谢产物。多酚及其肠道代谢产物可通过多种机制极大地影响宿主能量代谢。
目的
本综述旨在阐述肠道微生态在膳食多酚及其代谢产物对能量代谢的调节作用中的作用。
方法
在本综述中，我们阐述了多酚与肠道微生态（包括肠道微生物群、肠道上皮细胞和黏膜免疫系统）之间相互作用调节能量代谢的潜在机制。
结果
多酚可以选择性地调节易感微生物的生长（例如降低厚壁菌门与拟杆菌门的比例，促进有益菌生长并抑制病原菌），还能改变细菌酶活性。此外，多酚可影响肠道上皮细胞的吸收和分泌，并改变肠道黏膜免疫系统。
结论
肠道微生态在膳食多酚对能量代谢的调节中起关键作用。
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