Almazov National Medical Research Centre, Ministry of Healthcare of Russian Federation, St. Petersburg, Russia; Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia.
Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia; Granov Russian Research Centre of Radiology and Surgical Technologies, Ministry of Healthcare of Russian Federation, St. Petersburg, Russia.
Aquat Toxicol. 2019 May;210:44-55. doi: 10.1016/j.aquatox.2019.02.015. Epub 2019 Feb 20.
Intraspecies variation is common in both clinical and animal research of various brain disorders. Relatively well-studied in mammals, intraspecies variation in aquatic fish models and its role in their behavioral and pharmacological responses remain poorly understood. Like humans and mammals, fishes show high variance of behavioral and drug-evoked responses, modulated both genetically and environmentally. The zebrafish (Danio rerio) has emerged as a particularly useful model organism tool to access neurobehavioral and drug-evoked responses. Here, we discuss recent findings and the role of the intraspecies variance in neurobehavioral, pharmacological and toxicological studies utilizing zebrafish and other fish models. We also critically evaluate common sources of intraspecies variation and outline potential strategies to improve data reproducibility and translatability.
种内变异性在各种脑疾病的临床和动物研究中都很常见。在哺乳动物中研究得相对较好，但水生鱼类模型中的种内变异性及其在行为和药理学反应中的作用仍知之甚少。与人类和哺乳动物一样，鱼类的行为和药物诱发反应存在很大差异，这些差异受遗传和环境的调节。斑马鱼（Danio rerio）已成为一种特别有用的模式生物工具，可用于研究神经行为和药物诱发的反应。在这里，我们讨论了利用斑马鱼和其他鱼类模型进行神经行为、药理学和毒理学研究的最新发现和种内变异性的作用。我们还批判性地评估了种内变异性的常见来源，并概述了提高数据重现性和可翻译性的潜在策略。
