Sun Yu, Ma Xiaobin, Liu Jianxun
Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
Zhongguo Zhong Yao Za Zhi. 2012 Jan;37(1):61-5.
In order to investigate the chemical constituents from the fraction with cardiovascular activtiy of Chrysanthemum indicum, the isolation and purification of compounds from this active fraction were performed, and the chemical structures were elucidated by spectral analysis and comparison of the spectral data with those reported in the literature. As a result, twelve compounds were obtained and identified as (2S) -eriodictyol-7-O-beta-D-glucuronide (1), (2S) -eriodictyol-7-O-beta-D-glucoside (2), (2S) -hesperetin-7-O-beta-D-glucuronide (3), luteolin-7-O-beta-D-glucoside (4), luteolin-7-O-beta-D-glucuronide (5), diosmetin-7-O-beta-D-glucuronide (6), quercetin -7-O-beta-D-glucoside (7), (2S)-eriodict-dicaffeoylquinate (8), 3, 5-dicaffeoylquinic acid(9), 3, 5-cis-dicaffeoylquinic acid (10), 1, 5-dicaffeoylquinic acid (11), and 1, 3-dicaffeoylquinic acid (12). The above result indicated that flavonoids were the ma-dicaffeoylquinate (8), 3, 5-dicaffeoylquinic acid (9), 3, 5-cis-dicaffeoylquinic acid (10), 1, 5-dicaffeoylquinic acid (11), and 1, 3-dicaffeoylquinic acid (12). The above result indicated that flavonoids were the major components of the active fraction. Compounds 2, 3, 7, 8 and 10 were obtained from this genus for the first time, and compounds 5, 6, 9, 11, and 12 were first isolated from C. indicum.
为了研究野菊花具有心血管活性部位的化学成分，对该活性部位的化合物进行了分离纯化，并通过光谱分析以及将光谱数据与文献报道的数据进行比较来阐明其化学结构。结果，获得了12种化合物，分别鉴定为(2S)-圣草酚-7-O-β-D-葡萄糖醛酸苷(1)、(2S)-圣草酚-7-O-β-D-葡萄糖苷(2)、(2S)-橙皮素-7-O-β-D-葡萄糖醛酸苷(3)、木犀草素-7-O-β-D-葡萄糖苷(4)、木犀草素-7-O-β-D-葡萄糖醛酸苷(5)、香叶木素-7-O-β-D-葡萄糖醛酸苷(6)、槲皮素-7-O-β-D-葡萄糖苷(7)、(2S)-圣草酚二咖啡酰奎尼酸(8)、3,5-二咖啡酰奎尼酸(9)、3,5-顺式二咖啡酰奎尼酸(10)、1,5-二咖啡酰奎尼酸(11)和1,3-二咖啡酰奎尼酸(12)。上述结果表明黄酮类化合物是该活性部位的主要成分。化合物2、3、7、8和10首次从该属植物中获得，化合物5、6、9、11和12首次从野菊花中分离得到。
