Hua Yanjun, Pan Chao, Wang Qinmei
Department of Ophthalmology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, No. 600, Yishan Road, Xuhui District, Shanghai, 200233, China.
Aier Eye Hospital, Wuhan, China.
Int Ophthalmol. 2019 Nov;39(11):2467-2475. doi: 10.1007/s10792-019-01089-6. Epub 2019 Mar 1.
To develop a new regression formula based on the Gaussian thick lens formula and to verify the accuracy of the regression formula.
In this prospective study, 207 eyes of 207 myopic subjects and 133 eyes of 67 postoperative subjects were included. For the 133 postoperative eyes, 127 eyes underwent laser-assisted in situ keratomileusis, and 6 eyes underwent photorefractive keratectomy. Subjective refraction and Pentacam HR were performed preoperatively and postoperatively, and IOLMaster was performed in the postoperative group. SimK, keratometry based on the Gaussian optic formula (K), K obtained using the clinical history method, and the regression formulas K and K were calculated.
(1) A statistically significant difference (t = 155.164, P = 0.000) between SimK and K of 1.24 ± 0.12 D was observed, and there was a good correlation between SimK and K (r = 0.996, P = 0.000). The first regression formula (K = 0.351 + 1.021 × K) was obtained using linear regression. (2) Statistically significant differences (t = 19.114, - 25.184, 4.702, and all P = 0.000) between SimK and K, K and K and K and K of 0.75 ± 0.45 D, 0.96 ± 0.44 D and 0.18 ± 0.43 D, respectively, were obtained. Good correlations between SimK and K, K and K and K and K (all r ≧ 0.977, all Ps = 0.000) were also observed. The regression formula (K = - 1.204 + 1.027 × K) was obtained using linear regression. (3) Six methods were used for the prediction of IOL power in the postoperative group. The highest results were obtained from the Shammas formula (without preoperative data) combining K (obtained by IOLMaster) followed by the K and K combining Haigis formula. The third was obtained from the K and K combining Hoffer Q formula; and the smallest was the K combining Haigis formula.
The IOL power predicted by K in eyes after myopic CRS may be accurate.
基于高斯厚透镜公式开发一种新的回归公式，并验证该回归公式的准确性。
在这项前瞻性研究中，纳入了207例近视患者的207只眼以及67例术后患者的133只眼。对于133只术后眼，127只眼接受了准分子原位角膜磨镶术，6只眼接受了光性屈光性角膜切削术。术前和术后进行了主观验光和Pentacam HR检查，术后组进行了IOLMaster检查。计算了SimK、基于高斯光学公式的角膜曲率计测量值（K）、使用临床病史法获得的K以及回归公式K和K。
（1）观察到SimK与K之间存在1.24±0.12D的统计学显著差异（t = 155.164，P = 0.000），且SimK与K之间存在良好的相关性（r = 0.996，P = 0.000）。使用线性回归获得了第一个回归公式（K = 0.351 + 1.021×K）。（2）分别获得了SimK与K、K与K以及K与K之间的统计学显著差异（t = 19.114、-25.184、4.702，所有P = 0.000），差异分别为0.75±0.45D、0.96±0.44D和0.18±0.43D。还观察到SimK与K、K与K以及K与K之间存在良好的相关性（所有r≥0.977，所有P = 0.000）。使用线性回归获得了回归公式（K = -1.204 + 1.027×K）。（3）在术后组中使用六种方法预测人工晶状体度数。结果最高的是结合K（通过IOLMaster获得）的Shammas公式（无术前数据），其次是结合Haigis公式的K和K。第三是结合Hoffer Q公式的K和K；最小的是结合Haigis公式的K。
近视角膜屈光手术后眼用K预测的人工晶状体度数可能是准确的。
