肠易激综合征患者可发酵低聚糖、二糖、单糖和多元醇饮食摄入的个体内及个体间差异
Within- and Between-Subject Variation in Dietary Intake of Fermentable Oligo-, Di-, Monosaccharides, and Polyols Among Patients with Irritable Bowel Syndrome.
作者信息
Nybacka Sanna, Störsrud Stine, Liljebo Therese, Le Nevé Boris, Törnblom Hans, Simrén Magnus, Winkvist Anna
机构信息
Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
The City Gastrodepartment, Stockholm, Sweden.
出版信息
Curr Dev Nutr. 2018 Dec 24;3(2):nzy101. doi: 10.1093/cdn/nzy101. eCollection 2019 Feb.
BACKGROUND
A diet low in fermentable carbohydrates, fermentable oligo-, di-, monosaccharides, and polyols (FODMAPs) is a promising treatment option for patients with irritable bowel syndrome (IBS). In order to correctly estimate and study the intake of FODMAPs, information about within- and between-subject variations in intakes is needed, but is currently lacking.
OBJECTIVES
The aim was to characterize the variation in FODMAP intake among patients with IBS and to calculate how many days of observations are required to capture absolute intakes as well as to rank individuals.
METHODS
Food intake was recorded during 4 consecutive days, and intakes of energy and FODMAPs were calculated. The coefficient of variation within subjects (CV), coefficient of variation between subjects (CV), number of days required to estimate an individual's intake, and number of observations required to correctly rank individuals into quartiles of consumption were calculated.
RESULTS
Diet records were provided from 151 women and 46 men with IBS. The reported mean energy intake was 2039 ± 502 kcal among women and 2385 ± 573 kcal among men, and the median FODMAP intakes were 18.7 g (range 3.7-73.4) and 22.8 g (range 3.6-165.7), respectively. The ratio of CV/CV for total FODMAP intake was 0.83 for women and 0.67 for men, and below 1 for all FODMAPs. To capture intake of FODMAPs at the individual level, 19 d of observations are required. Ranking individuals within a group would require 2-6 d of observations.
CONCLUSION
There is more variation between subjects than within subjects regarding FODMAP intake. To correctly estimate an individual's absolute intake of FODMAPs, the number of days of diet records required exceeds what is reasonable for a participant to accomplish. However, ranking individuals into quartiles of FODMAP consumption can be achieved using a 4-d food record. This trial was registered at www.clinicaltrials.gov as NCT02107625 and NCT01252550.
背景
低可发酵碳水化合物、可发酵寡糖、双糖、单糖和多元醇（FODMAPs）饮食是肠易激综合征（IBS）患者一种有前景的治疗选择。为了正确估计和研究FODMAPs的摄入量，需要有关个体内和个体间摄入量变化的信息，但目前尚缺乏此类信息。
目的
旨在描述IBS患者中FODMAP摄入量的变化特征，并计算需要多少天的观察来获取绝对摄入量以及对个体进行排名。
方法
连续4天记录食物摄入量，并计算能量和FODMAPs的摄入量。计算个体内变异系数（CV）、个体间变异系数（CV）、估计个体摄入量所需的天数以及将个体正确排名到消费四分位数所需的观察次数。
结果
提供了151名女性和46名男性IBS患者的饮食记录。报告的女性平均能量摄入量为2039±502千卡，男性为2385±573千卡，FODMAPs的中位数摄入量分别为18.7克（范围3.7 - 73.4）和22.8克（范围3.6 - 165.7）。女性总FODMAP摄入量的CV/CV比值为0.83，男性为0.67，所有FODMAPs的该比值均低于1。要在个体水平上获取FODMAPs的摄入量，需要19天的观察。在一组内对个体进行排名需要2 - 6天的观察。
结论
关于FODMAP摄入量，个体间的变异比个体内的变异更大。要正确估计个体FODMAPs的绝对摄入量，所需的饮食记录天数超出了参与者能够合理完成的范围。然而，使用4天的食物记录可以将个体排名到FODMAP消费的四分位数。该试验在www.clinicaltrials.gov上注册，注册号为NCT02107625和NCT01252550。
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