Shen Wen, Zhang Guanghua, Ge Xuemei, Li Yali, Fan Guodong
School of Food and Biological Engineering, Shaanxi University of Science and Technology, Xi'an 710021, Shaanxi, People's Republic of China.
College of Chemistry and Chemical Engineering, Shaanxi University of Science and Technology, Xi'an 710021, Shaanxi, People's Republic of China.
R Soc Open Sci. 2018 Sep 12;5(9):180134. doi: 10.1098/rsos.180134. eCollection 2018 Sep.
Polylactic electrospun porous fibres have been widely used in tissue engineering scaffolds. However, the application of linear polylactic is limited due to its poor hydrophilicity, which leads to phase separation and has been seldom used in porous fibre preparation. Instead, branching polylactic acts as a new effective method to prepare porous fibres because it can increase polylactic polar property and make it easy to be formulated in the following application. In the current study, we prepared an ultra-high molecular weight of high branching polylactic with glycerol as the initiator by controlling the ring-opening polymerization time, adding amount of catalyst and glycerol. The structure, molecular weight and thermal properties of copolymers were tested subsequently. The result showed that the surface of the high branching polylactic films is smooth, hydrophilic and porous. This branching polylactic formed electrospun porous fibres and possessed a strong adsorption of silver ion. Our study provided a simple and efficient way to synthesize branching polylactic polymer and prepare electrospun porous fibres, which may provide potential applications in the field of biomaterials for tissue engineering or antibacterial dressing compared with the application of linear polylactic and 3-arm polylactic materials.
聚乳酸电纺多孔纤维已广泛应用于组织工程支架。然而，线性聚乳酸由于其亲水性差，导致相分离，应用受到限制，很少用于多孔纤维制备。相反，支化聚乳酸作为一种制备多孔纤维的新有效方法，因为它可以增加聚乳酸的极性，使其在后续应用中易于加工。在本研究中，我们以甘油为引发剂，通过控制开环聚合时间、催化剂用量和甘油用量，制备了超高分子量的高支化聚乳酸。随后测试了共聚物的结构、分子量和热性能。结果表明，高支化聚乳酸薄膜表面光滑、亲水且多孔。这种支化聚乳酸形成了电纺多孔纤维，并对银离子具有很强的吸附作用。我们的研究提供了一种简单有效的方法来合成支化聚乳酸聚合物并制备电纺多孔纤维，与线性聚乳酸和三臂聚乳酸材料的应用相比，这可能在生物材料领域为组织工程或抗菌敷料提供潜在应用。
