Center for Diagnostic Nanosystems, Marshall University, Huntington, WV, United States of America. Department of Internal Medicine, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, United States of America. Biotechnology Graduate Program West Virginia State University, Institute, WV, United States of America. Department of Health and Human Service, School of Kinesiology, Marshall University, Huntington, WV, United States of America.
Nanotechnology. 2019 Sep 13;30(37):372001. doi: 10.1088/1361-6528/ab0d38. Epub 2019 Mar 6.
The field of nanotechnology is rapidly growing. The promise of pharmacotherapeutics emerging from this vast field has drawn the attention of many researchers. However, with the increase in the prevalence of antibiotic resistant microorganisms, the manifestations of these promises are needed now more than ever. Many have postulated the antimicrobial potential of nanoparticle constructs derived from precious metals/noble metals nanoparticles (NMNPs), such as silver nanoparticles that show activity against multidrug resistant bacteria. In this review we will evaluate the current studies and explore the data to obtain a clear picture of the potential of these particles and the validity of the claims of drug resistant treatments with NMNPs.
纳米技术领域正在迅速发展。这一广阔领域中出现的药物治疗前景引起了许多研究人员的关注。然而,随着抗生素耐药微生物的流行率不断上升,现在比以往任何时候都更需要这些前景的表现。许多人推测,源自贵金属/稀有金属纳米颗粒(NMNPs)的纳米颗粒结构具有抗菌潜力,例如对多药耐药细菌具有活性的银纳米颗粒。在这篇综述中,我们将评估当前的研究,并探索数据,以清楚地了解这些颗粒的潜力以及使用 NMNPs 进行耐药治疗的主张的有效性。