长链非编码RNA POU3F3通过使半胱天冬酶9失活来促进三阴性乳腺癌中癌细胞的增殖并抑制其凋亡。
LncRNA POU3F3 promotes proliferation and inhibits apoptosis of cancer cells in triple-negative breast cancer by inactivating caspase 9.
作者信息
Yang Jun, Meng Xuli, Yu Yong, Pan Lei, Zheng Qinghui, Lin Wei
机构信息
a Department of breast and thyroid surgery , Tongde Hospital , Zhejiang Province , PR. China.
b Department of Breast and Thyroid Surgery , People's hospital of Quzhou City , Zhejiang Province , PR. China.
出版信息
Biosci Biotechnol Biochem. 2019 Jun;83(6):1117-1123. doi: 10.1080/09168451.2019.1588097. Epub 2019 Mar 7.
It has been reported that lncRNA POU3F3 was upregulated in esophageal squamous-cell carcinomas, indicating its role as an oncogene in this disease. However, the mechanism of its function and its involvement in other malignancies is unknown. In the present study we found that expression levels of lncRNA POU3F3 were higher in tumor tissues than in adjacent healthy tissues of triple negative breast cancer (TNBC) patients and were significantly and inversely correlated with levels of cleaved caspase 9 only in tumor tissues. In addition, plasma levels of lncRNA POU3F3 were higher in TNBC patients than in healthy controls and were significantly and inversely correlated with levels of cleaved caspase 9 only in TNBC patients. In addition, treatment of exogenous Cleaved Caspase-9 significantly attenuated the effects of lncRNA POU3F3 overexpression on cancer cell proliferation and apoptosis. lncRNA POU3F3 may promote proliferation and inhibit apoptosis of cancer cells in triple-negative breast cancer.
据报道，lncRNA POU3F3在食管鳞状细胞癌中上调，表明其在该疾病中作为癌基因发挥作用。然而，其功能机制及其在其他恶性肿瘤中的作用尚不清楚。在本研究中，我们发现lncRNA POU3F3在三阴性乳腺癌（TNBC）患者的肿瘤组织中的表达水平高于相邻的健康组织，并且仅在肿瘤组织中与裂解的caspase 9水平呈显著负相关。此外，TNBC患者血浆中lncRNA POU3F3水平高于健康对照，并且仅在TNBC患者中与裂解的caspase 9水平呈显著负相关。此外，外源性裂解的Caspase-9处理显著减弱了lncRNA POU3F3过表达对癌细胞增殖和凋亡的影响。lncRNA POU3F3可能促进三阴性乳腺癌中癌细胞的增殖并抑制其凋亡。
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