药物-纳米金刚石复合物的肿瘤选择性摄取可改善胰腺癌的治疗效果。
Tumor selective uptake of drug-nanodiamond complexes improves therapeutic outcome in pancreatic cancer.
机构信息
Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Jacksonville, FL, United States.
Division of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
出版信息
Nanomedicine. 2019 Jun;18:112-121. doi: 10.1016/j.nano.2019.02.020. Epub 2019 Mar 6.
Abstract
Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer-related deaths and novel treatment approaches are urgently needed. Here we show that poly(ethylene glycol)-functionalized nanodiamonds loaded with doxorubicin (ND-PEG-DOX) afforded a considerable improvement over free drug in an orthotopic pancreatic xenograft model. ND-PEG-DOX complexes were also superior to free DOX in 3-dimensional (3D) tumor spheroids of PDAC. ND-PEG showed no cytotoxicity towards macrophages, and histopathological analysis showed no abnormalities of major organs upon in vivo administration of ND-PEG-DOX. These results provide evidence that ND-mediated drug delivery may serve as a means of improving the therapeutic outcome in PDAC.
摘要
胰腺导管腺癌 (PDAC) 是癌症相关死亡的主要原因之一，迫切需要新的治疗方法。在这里，我们表明，载多柔比星的聚乙二醇化纳米金刚石 (ND-PEG-DOX) 在原位胰腺异种移植模型中比游离药物有了相当大的改善。ND-PEG-DOX 复合物在 PDAC 的三维 (3D) 肿瘤球体中也优于游离 DOX。ND-PEG 对巨噬细胞没有细胞毒性，体内给予 ND-PEG-DOX 后组织病理学分析未显示主要器官异常。这些结果表明，ND 介导的药物递送可能是改善 PDAC 治疗效果的一种手段。
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本文引用的文献
1
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J Mater Chem B. 2016 Aug 7;4(29):5046-5058. doi: 10.1039/c6tb00266h. Epub 2016 Jul 13.
2
Cloaking nanoparticles with protein corona shield for targeted drug delivery.用蛋白质冠层包裹隐形纳米粒子进行靶向药物递送。
Nat Commun. 2018 Oct 31;9(1):4548. doi: 10.1038/s41467-018-06979-4.
3
Mapping of the available standards against the regulatory needs for nanomedicines.对纳米药物的监管需求与现有标准进行对照。
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2019 Jan;11(1):e1531. doi: 10.1002/wnan.1531. Epub 2018 Jun 20.
4
Progress and challenges towards targeted delivery of cancer therapeutics.癌症治疗靶向递药的进展与挑战。
Nat Commun. 2018 Apr 12;9(1):1410. doi: 10.1038/s41467-018-03705-y.
5
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Nat Rev Cancer. 2018 Jul;18(7):452-464. doi: 10.1038/s41568-018-0005-8.
6
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Exp Mol Med. 2017 Dec 1;49(12):e406. doi: 10.1038/emm.2017.255.
7
Targeted Therapies for Pancreatic Cancer.胰腺癌的靶向治疗
Cancers (Basel). 2018 Jan 29;10(2):36. doi: 10.3390/cancers10020036.
8
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10
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Nat Rev Cancer. 2017 Nov;17(11):659-675. doi: 10.1038/nrc.2017.83. Epub 2017 Oct 13.
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