Deng Haiyou, Jia Ya, Zhang Yang
College of Science, Huazhong Agricultural University, Wuhan 4R0070, P. R. China.
College of Physical Science and Technology, Central China Normal University, Wuhan 430079, P. R. China.
Int J Mod Phys B. 2018 Jul 20;32(18). doi: 10.1142/S021797921840009X. Epub 2017 Dec 11.
Predicting 3D structure of protein from its amino acid sequence is one of the most important unsolved problems in biophysics and computational biology. This paper attempts to give a comprehensive introduction of the most recent effort and progress on protein structure prediction. Following the general flowchart of structure prediction, related concepts and methods are presented and discussed. Moreover, brief introductions are made to several widely-used prediction methods and the community-wide critical assessment of protein structure prediction (CASP) experiments.
从氨基酸序列预测蛋白质的三维结构是生物物理学和计算生物学中最重要的尚未解决的问题之一。本文试图全面介绍蛋白质结构预测方面的最新成果和进展。按照结构预测的一般流程图，介绍并讨论了相关概念和方法。此外，还简要介绍了几种广泛使用的预测方法以及蛋白质结构预测的社区范围关键评估（CASP）实验。
