Departamento de Química, Facultad de Ciencias Naturales, Matemáticas y del Medio Ambiente, Universidad Tecnológica Metropolitana, Las Palmeras 3360, Santiago 7800003, Chile.
Programa Institucional de Fomento a la Investigación, Desarrollo e Innovación, Universidad Tecnológica Metropolitana, Ignacio Valdivieso 2409, Santiago 8940577, Chile.
Int J Mol Sci. 2019 Mar 10;20(5):1210. doi: 10.3390/ijms20051210.
Three-dimensional (3D) printing technologies can be widely used for producing detailed geometries based on individual and particular demands. Some applications are related to the production of personalized devices, implants (orthopedic and dental), drug dosage forms (antibacterial, immunosuppressive, anti-inflammatory, etc.), or 3D implants that contain active pharmaceutical treatments, which favor cellular proliferation and tissue regeneration. This review is focused on the generation of 3D printed polymer-based objects that present antibacterial properties. Two main different alternatives of obtaining these 3D printed objects are fully described, which employ different polymer sources. The first one uses natural polymers that, in some cases, already exhibit intrinsic antibacterial capacities. The second alternative involves the use of synthetic polymers, and thus takes advantage of polymers with antimicrobial functional groups, as well as alternative strategies based on the modification of the surface of polymers or the elaboration of composite materials through adding certain antibacterial agents or incorporating different drugs into the polymeric matrix.
三维(3D)打印技术可以广泛用于根据个人和特定需求生产详细的几何形状。一些应用与个性化设备、植入物(骨科和牙科)、药物剂型(抗菌、免疫抑制、抗炎等)或含有活性药物治疗的 3D 植入物的生产有关,这些治疗方法有利于细胞增殖和组织再生。本综述重点介绍了具有抗菌性能的 3D 打印聚合物基物体的生成。详细描述了获得这些 3D 打印物体的两种主要不同方法,它们使用不同的聚合物来源。第一种方法使用天然聚合物,在某些情况下,这些聚合物已经具有内在的抗菌能力。第二种方法涉及使用合成聚合物,因此利用具有抗菌官能团的聚合物,以及基于聚合物表面改性或通过添加某些抗菌剂或在聚合物基质中掺入不同药物来制备复合材料的替代策略。