Department of Biochemistry and Molecular Genetics, University of Colorado Denver-Anschutz Medical Campus, Aurora, Colorado.
Department of Medicine, Division of Hematology, University of Colorado Denver-Anschutz Medical Campus, Aurora, Colorado.
Transfusion. 2019 May;59(5):1620-1623. doi: 10.1111/trf.15248. Epub 2019 Mar 13.
Red blood cell (RBC) storage in the blood bank is characterized by the progressive loss of metabolic regulation, a phenomenon that targets energy and antioxidant metabolism; While the progression of the storage lesion is inevitable, the rate at which this phenomenon occurs varies from donor to donor; Red blood cells from some donors at the end of storage are metabolically superior to RBCs from other donors at the beginning of storage, suggesting that the age of blood alone may not be a sufficiently accurate predictor of stored blood quality; and Animal studies and large-scale omics screening in blood donors have helped identify mechanistic contributors to the metabolic heterogeneity of stored blood units.
血库中红细胞（RBC）的储存特点是代谢调节逐渐丧失，这种现象针对能量和抗氧化代谢；虽然储存损伤的进展是不可避免的，但这种现象发生的速度因供体而异；一些供体在储存末期的红细胞在代谢上优于其他供体在储存初期的红细胞，这表明血液的年龄本身可能不是储存血液质量的一个足够准确的预测指标；动物研究和对献血者的大规模组学筛选有助于确定储存血单位代谢异质性的机制贡献者。
