TFIIIA及同源基因。“锌指”蛋白。
TFIIIA and homologous genes. The 'finger' proteins.
作者信息
Vincent A
出版信息
Nucleic Acids Res. 1986 Jun 11;14(11):4385-91. doi: 10.1093/nar/14.11.4385.
Abstract
Differential regulation of gene expression, in a precise temporal and spatial pattern during development, is thought to be partly mediated by site specific DNA binding proteins which promote a selective activation of gene transcription. From studies on Xenopus TFIIIA, a factor selectively required for transcription of 5 S ribosomal RNA genes, Miller et al. proposed a novel structural model of interaction between DNA and DNA binding protein. The striking homology of TFIIIA with several recently sequenced Drosophila and yeast gene products suggests that multiple regulatory proteins may have evolved from a small ancestral DNA binding protein domain and that the characteristic features of TFIIIA and TFIIIA-5S DNA interactions may be of general significance.
摘要
在发育过程中，基因表达的差异调控以精确的时间和空间模式进行，人们认为这部分是由位点特异性DNA结合蛋白介导的，这些蛋白促进基因转录的选择性激活。通过对非洲爪蟾TFIIIA（一种5S核糖体RNA基因转录选择性所需的因子）的研究，米勒等人提出了一种DNA与DNA结合蛋白相互作用的新型结构模型。TFIIIA与最近测序的几种果蝇和酵母基因产物具有显著的同源性，这表明多种调控蛋白可能是从一个小的祖先DNA结合蛋白结构域进化而来的，并且TFIIIA和TFIIIA-5S DNA相互作用的特征可能具有普遍意义。
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