Heagerty A M, Ollerenshaw J D, Robertson D I, Bing R F, Swales J D
Br Med J (Clin Res Ed). 1986 Aug 2;293(6542):295-7. doi: 10.1136/bmj.293.6542.295.
In a randomised double blind study to determine whether an increase in the polyunsaturated fat linoleic acid might influence leucocyte membrane sodium transport 22 normotensive volunteers received an oral supplement of linoleic acid or placebo daily for four weeks. Mean total sodium efflux rose significantly during supplementation with linoleic acid compared with placebo. In addition, all components of lying and standing blood pressure fell, though only the fall in supine systolic pressure was significant. Dietary supplementation with linoleic acid may alter ion fluxes across the cell membrane, presumably through changes in its physicochemical structure. In addition, the change in fat intake may lower blood pressure, though to only a very modest extent.
在一项随机双盲研究中，为了确定多不饱和脂肪酸亚油酸的增加是否会影响白细胞膜钠转运，22名血压正常的志愿者连续四周每天口服亚油酸补充剂或安慰剂。与安慰剂相比，补充亚油酸期间平均总钠外流显著增加。此外，卧位和立位血压的所有组成部分均下降，尽管只有仰卧位收缩压的下降具有显著性。亚油酸膳食补充剂可能会改变跨细胞膜的离子通量，大概是通过其物理化学结构的变化。此外，脂肪摄入量的改变可能会降低血压，尽管幅度非常小。
