Zanetti M
Crit Rev Immunol. 1986;6(2):151-83.
The manuscript will deal with various aspects of the origin of autoantibody formation in relationship with idiotypy. The proposed analysis will cover three major aspects: (1) overview of the published data on idiotypic characterization of autoantibodies in various systems by conventional serologic investigation; (2) presentation of the structural and genetic data available for autoantibodies; and (3) description of the most significant experiment of in vivo manipulation of autoantibody production using idiotypy as the central element for immune regulation. The manuscript will also discuss some theoretical aspects of regulation by idiotype and its possible relevance to improve our understanding of autoreactivity as well as the pathogenesis of certain autoimmune diseases.
该手稿将探讨自身抗体形成的起源与独特型相关的各个方面。拟议的分析将涵盖三个主要方面：（1）通过传统血清学研究对各种系统中自身抗体独特型特征的已发表数据进行概述；（2）提供自身抗体的结构和遗传数据；（3）描述以独特型作为免疫调节核心要素的体内自身抗体产生操纵的最重要实验。该手稿还将讨论独特型调节的一些理论方面及其与增进我们对自身反应性以及某些自身免疫性疾病发病机制的理解的可能相关性。
