Department of Biomechanical Engineering, Faculty of Mechanical, Maritime, and Materials Engineering, Delft University of Technology (TU Delft), Mekelweg 2, Delft 2628CD, The Netherlands.
Product Development Group Zurich, Institute of Design, Material and Fabrication, Department of Mechanical and Process Engineering, Swiss Federal Institute of Technology (ETH Zurich), Leonhardstrasse 21, 8092 Zurich, Switzerland.
Int J Mol Sci. 2019 Mar 20;20(6):1407. doi: 10.3390/ijms20061407.
Clinical use of bioengineered skin in reconstructive surgery has been established for more than 30 years. The limitations and ethical considerations regarding the use of animal models have expanded the application of bioengineered skin in the areas of disease modeling and drug screening. These skin models should represent the anatomical and physiological traits of native skin for the efficient replication of normal and pathological skin conditions. In addition, reliability of such models is essential for the conduction of faithful, rapid, and large-scale studies. Therefore, research efforts are focused on automated fabrication methods to replace the traditional manual approaches. This report presents an overview of the skin models applicable to skin disease modeling along with their fabrication methods, and discusses the potential of the currently available options to conform and satisfy the demands for disease modeling and drug screening.
生物工程皮肤在整形手术中的临床应用已经超过 30 年。由于动物模型的应用存在局限性和伦理问题，生物工程皮肤在疾病建模和药物筛选领域的应用得到了扩展。这些皮肤模型应代表天然皮肤的解剖学和生理学特征，以有效复制正常和病理皮肤状况。此外，此类模型的可靠性对于进行真实、快速和大规模的研究至关重要。因此，研究工作集中在自动化制造方法上，以取代传统的手动方法。本报告概述了适用于皮肤疾病建模的皮肤模型及其制造方法，并讨论了目前可用选项在满足疾病建模和药物筛选需求方面的潜力。
