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硫氧还蛋白还原酶参与了……的发育和致病性。 （原文句末不完整）

Thioredoxin Reductase Is Involved in Development and Pathogenicity in .

作者信息

Fan Xinyue, He Fang, Ding Mingyu, Geng Chao, Chen Lei, Zou Shenshen, Liang Yuancun, Yu Jinfeng, Dong Hansong

机构信息

Key Laboratory of Agricultural Microbiology, College of Plant Protection, Shandong Agricultural University, Tai'an, China.

出版信息

Front Microbiol. 2019 Mar 7;10:393. doi: 10.3389/fmicb.2019.00393. eCollection 2019.

DOI:10.3389/fmicb.2019.00393
PMID:30899249
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6416177/
Abstract

is one of the causal agents of Fusarium head blight and produces the trichothecene mycotoxin, deoxynivalenol (DON). Thioredoxin reductases (TRRs) play critical roles in the recycling of oxidized thioredoxin. However, their functions are not well known in plant pathogenic fungi. In this study, we characterized a TRR orthologue FgTRR in . The FgTRR-GFP fusion protein localized to the cytoplasm. gene deletion demonstrated that FgTRR is involved in hyphal growth, conidiation, sexual reproduction, DON production, and virulence. The Δ mutants also exhibited a defect in pigmentation, the expression level of aurofusarin biosynthesis-related genes was significantly decreased in the mutant. Furthermore, the Δ mutants were more sensitive to oxidative stress and aggravated apoptosis-like cell death compared with the wild type strain. Taken together, these results indicate that is important in development and pathogenicity in .

摘要

是小麦赤霉病的致病因子之一，并产生单端孢霉烯族毒素脱氧雪腐镰刀菌烯醇（DON）。硫氧还蛋白还原酶（TRRs）在氧化型硫氧还蛋白的循环利用中起关键作用。然而，它们在植物病原真菌中的功能尚不清楚。在本研究中，我们对中的一个TRR直系同源物FgTRR进行了表征。FgTRR-GFP融合蛋白定位于细胞质。基因缺失表明FgTRR参与菌丝生长、分生孢子形成、有性生殖、DON产生和毒力。Δ突变体在色素沉着方面也表现出缺陷，在突变体中，金孢子素生物合成相关基因的表达水平显著降低。此外，与野生型菌株相比，Δ突变体对氧化应激更敏感，凋亡样细胞死亡加剧。综上所述，这些结果表明在的发育和致病性中很重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e8a/6416177/43099a886b51/fmicb-10-00393-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e8a/6416177/87bb1fb70fb2/fmicb-10-00393-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e8a/6416177/9c8a722d0971/fmicb-10-00393-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e8a/6416177/84e82f1e3aeb/fmicb-10-00393-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e8a/6416177/c975679dfbe3/fmicb-10-00393-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e8a/6416177/009ccdd54b0a/fmicb-10-00393-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e8a/6416177/478d46d0911c/fmicb-10-00393-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e8a/6416177/edcc4aa8ae59/fmicb-10-00393-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e8a/6416177/43099a886b51/fmicb-10-00393-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e8a/6416177/87bb1fb70fb2/fmicb-10-00393-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e8a/6416177/9c8a722d0971/fmicb-10-00393-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e8a/6416177/84e82f1e3aeb/fmicb-10-00393-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e8a/6416177/c975679dfbe3/fmicb-10-00393-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e8a/6416177/009ccdd54b0a/fmicb-10-00393-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e8a/6416177/478d46d0911c/fmicb-10-00393-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e8a/6416177/edcc4aa8ae59/fmicb-10-00393-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e8a/6416177/43099a886b51/fmicb-10-00393-g008.jpg

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