Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD.
Department of Clinical Research and Leadership, The George Washington University School of Medicine and Health Sciences, Washington, DC.
Ethn Dis. 2019 Feb 21;29(Suppl 1):179-186. doi: 10.18865/ed.29.S1.179. eCollection 2019.
Individuals with African ancestry have the greatest genomic diversity in the world, yet they have been underrepresented in genomic research. To advance our understanding of human biology and our ability to trace human history, we must include more samples from Africans in genomic research. Additionally, inclusion of more samples from participants of recent African descent is imperative to provide equitable health care as genomics is increasingly used for diagnosis, treatment, and to understand disease risk. The Human Heredity and Health in Africa initiative (H3Africa) seeks to expand the number of Africans included in genomic research and to do so by expanding the research capacity on the continent. In this article, we discuss how H3Africa is endeavoring to achieve these goals while promoting equitable research collaborations.
非洲裔个体拥有世界上最丰富的基因组多样性，但他们在基因组研究中的代表性不足。为了增进我们对人类生物学的理解以及追踪人类历史的能力，我们必须在基因组研究中纳入更多来自非洲人的样本。此外，纳入更多来自近期非洲裔参与者的样本对于提供公平的医疗保健至关重要，因为基因组学越来越多地用于诊断、治疗和了解疾病风险。人类遗传与健康在非洲倡议（H3Africa）旨在扩大参与基因组研究的非洲人的数量，并通过扩大非洲大陆的研究能力来实现这一目标。在本文中，我们将讨论 H3Africa 如何在努力实现这些目标的同时促进公平的研究合作。
