Wang Fei, Zhang Xueli, Liu Xiaoguo, Fan Chunhai, Li Qian
Joint Research Center for Precision Medicine, Shanghai Jiao Tong University and Affiliated Sixth People's Hospital South Campus, Southern Medical University Affiliated Fengxian Hospital, Shanghai, 201499, China.
School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.
Small. 2019 Jun;15(26):e1900013. doi: 10.1002/smll.201900013. Epub 2019 Mar 25.
DNA nanotechnology enables the precise fabrication of DNA-based machines with nanoscale dimensions. A wide range of DNA nanomachines are designed, which can be activated by specific inputs to perform various movement and functions. The excellent rigidity and unprecedented addressability of DNA origami have made it an excellent platform for manipulating and investigating the motion behaviors of DNA machines at single-molecule level. In this Concept, power supply, machine actuation, and motion behavior of DNA machines on origami platforms are summarized and classified. The strategies utilized for programming motion behavior of DNA machines on DNA origami are also discussed with representative examples. The challenges and outlook for future development of manipulating DNA nanomachines at the single molecule level are presented and discussed.
DNA纳米技术能够精确制造具有纳米尺度尺寸的基于DNA的机器。人们设计了各种各样的DNA纳米机器，它们可以通过特定的输入被激活，以执行各种运动和功能。DNA折纸出色的刚性和前所未有的可寻址性使其成为在单分子水平上操纵和研究DNA机器运动行为的优秀平台。在本概念中，总结并分类了DNA机器在折纸平台上的供电、机器驱动和运动行为。还通过代表性实例讨论了用于对DNA折纸平台上的DNA机器的运动行为进行编程的策略。介绍并讨论了在单分子水平上操纵DNA纳米机器未来发展面临的挑战和前景。
