School of Agriculture and Food Science, Institute of Food and Health, University College Dublin, Dublin 4, Ireland; email:
Annu Rev Food Sci Technol. 2019 Mar 25;10:479-519. doi: 10.1146/annurev-food-032818-121715.
Metabolomics is the study of small molecules called metabolites in biological samples. Application of metabolomics to nutrition research has expanded in recent years, with emerging literature supporting multiple applications. Key examples include applications of metabolomics in the identification and development of objective biomarkers of dietary intake, in developing personalized nutrition strategies, and in large-scale epidemiology studies to understand the link between diet and health. In this review, we provide an overview of the current applications and identify key challenges that need to be addressed for the further development of the field. Successful development of metabolomics for nutrition research has the potential to improve dietary assessment, help deliver personalized nutrition, and enhance our understanding of the link between diet and health.
代谢组学是研究生物样本中称为代谢物的小分子的科学。近年来，代谢组学在营养研究中的应用不断扩展，新出现的文献支持多种应用。其中的重要例子包括将代谢组学应用于识别和开发饮食摄入的客观生物标志物、制定个性化营养策略，以及在大规模流行病学研究中了解饮食与健康之间的联系。在这篇综述中，我们概述了当前的应用，并确定了该领域进一步发展需要解决的关键挑战。成功地将代谢组学应用于营养研究有可能改善饮食评估、提供个性化营养，并增进我们对饮食与健康之间联系的理解。
