Plague Unit, WHO Collaborating Center, Institut Pasteur, Antananarivo, Madagascar.
Unité de Biologie des Spirochètes, National Reference Centre for Leptospirosis, Institut Pasteur, Paris, France.
Am J Trop Med Hyg. 2019 May;100(5):1079-1081. doi: 10.4269/ajtmh.18-0642.
Leptospirosis is a neglected zoonotic bacterial disease caused by pathogenic spp. Only limited studies have been conducted on the presence of spp. in rats in Antananarivo, the capital city of Madagascar. We assessed prevalence in small mammals in urban areas of Antananarivo where sanitation is inadequate and there is risk of flooding during the rainy season. We captured rodents and shrews at two sites and examined kidney samples from 114 animals using culture and a real-time polymerase chain reaction (PCR) assay specific to pathogenic spp. We identified 23 positive samples containing and , with a high prevalence in (44.9%). Our results indicate that small mammals, in particular , present a major public health risk for acquiring leptospirosis in Antananarivo.
钩端螺旋体病是一种被忽视的人畜共患细菌性疾病，由致病性 spp. 引起。仅有限的研究已经对马达加斯加首都塔那那利佛的大鼠中 spp. 的存在进行了研究。我们评估了城市地区小型哺乳动物的流行情况，那里的卫生条件不足，雨季有洪水风险。我们在两个地点捕获了啮齿动物和鼩鼱，并使用针对致病性 spp. 的培养和实时聚合酶链反应（PCR）检测对 114 个动物的肾脏样本进行了检查。我们鉴定了 23 个含有 和 的阳性样本，其中 （44.9%）的患病率较高。我们的结果表明，小型哺乳动物，特别是 ，对塔那那利佛获得钩端螺旋体病构成了重大公共卫生风险。
