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调控有机/聚合物光学试剂的光物理性质以促进癌症光疗诊断。

Regulating the Photophysical Property of Organic/Polymer Optical Agents for Promoted Cancer Phototheranostics.

机构信息

State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education and College of Life Sciences, Nankai University, Tianjin, 300071, China.

出版信息

Adv Mater. 2020 Jan;32(3):e1806331. doi: 10.1002/adma.201806331. Epub 2019 Mar 29.

Abstract

On the basis of the Jablonski diagram, the photophysical properties of optical agents are highly associated with biomedical function and efficacy. Herein, the focus is on organic/polymer optical agents and the recent progress in the main strategies for regulating their photophysical properties to achieve superior cancer diagnosis/phototheranostics applications are highlighted. Both the approaches of nanoengineering and molecular design, which can lead to optimized effectiveness of required biomedical function, are discussed.

摘要

基于 Jablonski 图,光学试剂的光物理性质与生物医学功能和疗效密切相关。本文重点介绍有机/聚合物光学试剂,并强调了最近在调节其光物理性质以实现优异的癌症诊断/光热治疗应用的主要策略方面的进展。讨论了纳米工程和分子设计这两种方法,它们可以优化所需生物医学功能的效果。

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