Department of Rheumatology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, PR China.
Department of Pediatrics, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, PR China.
Clin Immunol. 2019 May;202:49-58. doi: 10.1016/j.clim.2019.03.008. Epub 2019 Mar 26.
The innate lymphoid cell (ILC) is a group of effector cells with diverse important cellular functions in both health and disease states. In comparison with healthy controls, there were increases in circulating ILC in SLE patients. The proportion of ILC1 significantly increased with significant decreases of ILC2 in SLE patients and ILC3 in SLE patients with moderate to severe activity. IL-12, IL-18, IL-25, IL-33, IL-23, IL-1β and IFN-γ were significantly increased in SLE patients. Moreover, IL-12, IL-18 and IL-1β but not IFN-γ correlated significantly with SLEDAI. Successful treatments rapidly reduced them and with certain normalization of the ILC subsets. In addition to increases in ILC1 numbers, ~ 80% of the ILC1 in SLE patients were positive for synthesis of IFN-γ. Plasma from SLE patients were shown to be potent in inducing ILC1. Thus, increased circulating ILC1 might contribute to the pathogenesis of SLE through mounting type 1 immune response.
固有淋巴细胞（ILC）是一组效应细胞，在健康和疾病状态下具有多种重要的细胞功能。与健康对照组相比，SLE 患者的循环 ILC 增加。SLE 患者中 ILC1 的比例显著增加，而 ILC2 的比例显著降低，SLE 患者中度至重度活动时 ILC3 的比例也降低。SLE 患者中 IL-12、IL-18、IL-25、IL-33、IL-23、IL-1β 和 IFN-γ 显著增加。此外，IL-12、IL-18 和 IL-1β 而非 IFN-γ 与 SLEDAI 显著相关。成功的治疗迅速降低了它们的水平，并使 ILC 亚群的某些功能恢复正常。除了 ILC1 数量的增加，SLE 患者中约 80%的 ILC1 阳性表达 IFN-γ。SLE 患者的血浆显示出很强的诱导 ILC1 的能力。因此，循环 ILC1 的增加可能通过引发 1 型免疫反应而导致 SLE 的发病机制。
