Durum S K, Gengozian N
Int J Radiat Biol Relat Stud Phys Chem Med. 1978 Jul;34(1):1-15. doi: 10.1080/09553007814550581.
This study deals with the comparative effects of gamma irradiation on T and B lymphocytes in mice. Quantitatively, splenic T cells appeared substantially more radioresistant than B cells. However, in the thymus, the mesenteric lymph node and peripheral blood, both cell types were highly radiosensitive. No repair processes could be detected with respect to lymphocyte killing, since reducing the dose rate or fractionating the dose resulted in no reduction in cell destruction. Splenic B cells which remained intact 3 days after doses of 600 R or larger were impaired in their ability to form caps, whereas T cells capped normally. Spleen cells which were viable 3 days after irradiation bore latent radiation damage which was manifested as a reduced ability to survive and generate plaque-forming cells in vitro. Attempts to separately assess irradiated T and B cell immunocompetence in vitro suggested that at doses of 300 R and below, surviving B cells were more impaired than T cells. After a 600 R dose, neither cell type appeared to be functional.
本研究探讨了γ射线照射对小鼠T淋巴细胞和B淋巴细胞的比较效应。从数量上看，脾脏T细胞似乎比B细胞对辐射更具抗性。然而，在胸腺、肠系膜淋巴结和外周血中，这两种细胞类型对辐射都高度敏感。在淋巴细胞杀伤方面未检测到修复过程，因为降低剂量率或分割剂量并未导致细胞破坏减少。在600伦琴或更高剂量照射3天后仍保持完整的脾脏B细胞形成帽的能力受损，而T细胞帽形成正常。照射3天后仍存活的脾细胞带有潜在的辐射损伤，表现为体外存活和产生空斑形成细胞的能力降低。在体外分别评估受照射T细胞和B细胞免疫能力的尝试表明，在300伦琴及以下剂量时，存活的B细胞比T细胞受损更严重。在600伦琴剂量后，两种细胞类型似乎都失去了功能。
