Department of General Courses, School of Management and Medical Information Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
Halal Research Center of IRI, FDA, Tehran, Iran.
Phytother Res. 2019 Jun;33(6):1616-1626. doi: 10.1002/ptr.6356. Epub 2019 Apr 5.
The impetus for the current study was to evaluate the efficacy of propolis supplementation on markers of glycemic status in adults with type 2 diabetes mellitus (T2DM).
A comprehensive search was conducted in PubMed, Scopus, Cochrane Library, Web of Science, and Google Scholar up to August 2018, identifying randomized controlled trials investigating the effect of propolis supplementation on glycemic markers in adults with T2DM. Cochrane Collaboration tool was used to evaluate the risk of bias assessment. A random-effects model was applied in the meta-analysis to compensate for potential heterogeneity among the included studies.
Six randomized controlled trials comprising 373 participants were included in the systematic review and meta-analysis. The results of the meta-analysis revealed significant reductions in fasting plasma glucose (-13.51 mg/dl; 95% CI [-24.98, -2.04]) and hemoglobin A1C (-0.52%; 95% CI [-0.94, -0.10]) concentrations following propolis supplementation. However, no significant lowering effect was observed in fasting insulin levels (-0.53 pmol/L; 95% CI [-1.69, 0.63]) or homeostasis model assessment of insulin resistance (-0.543; 95% CI [-1.72, 0.64]).
This systematic review and meta-analysis suggested that propolis supplementation may be effective in controlling glycemic levels for T2DM patients. Further studies are needed to confirm these results.
本研究旨在评估蜂胶补充剂对 2 型糖尿病（T2DM）成人血糖指标的疗效。
系统检索 PubMed、Scopus、Cochrane 图书馆、Web of Science 和 Google Scholar 数据库，检索时限截至 2018 年 8 月，收集蜂胶补充剂对 T2DM 成人血糖指标影响的随机对照试验。采用 Cochrane 协作工具评估偏倚风险。Meta 分析采用随机效应模型，以补偿纳入研究间的潜在异质性。
系统评价和 Meta 分析共纳入 6 项随机对照试验，共 373 例参与者。Meta 分析结果显示，蜂胶补充后空腹血糖（-13.51mg/dl；95%CI[-24.98，-2.04]）和糖化血红蛋白（HbA1C）浓度（-0.52%；95%CI[-0.94，-0.10]）显著降低。然而，蜂胶补充对空腹胰岛素水平（-0.53pmol/L；95%CI[-1.69，0.63]）或稳态模型评估的胰岛素抵抗（-0.543；95%CI[-1.72，0.64]）无显著降低作用。
本系统评价和 Meta 分析表明，蜂胶补充剂可能有助于控制 T2DM 患者的血糖水平。需要进一步的研究来证实这些结果。
