Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore-, 560012, India.
Centre for Nanoscience and Engineering, Indian Institute of Science, Bangalore-, 560012, India.
Angew Chem Int Ed Engl. 2019 Jun 3;58(23):7797-7801. doi: 10.1002/anie.201903427. Epub 2019 May 6.
In this study, we report a remarkably active CeVO nanozyme that functionally mimics cytochrome c oxidase (CcO), the terminal enzyme in the respiratory electron transport chain, by catalyzing a four-electron reduction of dioxygen to water. The nanozyme catalyzes the reaction by using cytochrome c (Cyt c), the biological electron donor for CcO, at physiologically relevant pH. The CcO activity of the CeVO nanozymes depends on the relative ratio of surface Ce /Ce ions, the presence of V and the surface-Cyt c interactions. The complete reduction of oxygen to water takes place without release of any partially reduced oxygen species (PROS) such as superoxide, peroxide and hydroxyl radicals.
在这项研究中，我们报告了一种非常活跃的 CeVO 纳米酶，它通过催化氧气的四电子还原为水，模拟细胞色素 c 氧化酶 (CcO) 的功能，后者是呼吸电子传递链中的末端酶。纳米酶通过在生理相关 pH 值下使用细胞色素 c (Cyt c)（CcO 的生物电子供体）来催化反应。CeVO 纳米酶的 CcO 活性取决于表面 Ce/Ce 离子的相对比例、V 的存在以及表面 Cyt c 相互作用。氧气完全还原为水，而没有释放任何部分还原的氧物质（PROS），如超氧化物、过氧化物和羟基自由基。
