聚己内酯膜修饰的316L不锈钢的表面及蛋白质吸附特性

Chang Shih-Hang, Hsiao Yuan-Chien

Department of Chemical and Materials Engineering, National I-Lan University, I-Lan 260, Taiwan.

Polymers (Basel). 2017 Oct 23;9(10):545. doi: 10.3390/polym9100545.

The surface and protein adsorption properties of 316L stainless steel (316L SS) modified with polycaprolactone (PCL) films are systematically investigated. The wettability of the PCL films was comparable to that of bare 316L SS because the rough surface morphology of the PCL films counteracts their hydrophobicity. Surface modification with PCL film significantly improves the corrosion resistance of the 316L SS because PCL is insulating in nature. A coating of PCL film effectively reduces the amount of adhered bovine serum albumin (BSA) on the surface of 316L SS in a bicinchoninic acid protein assay. PCL is both biodegradable and biocompatible, suggesting the potential for the surface modification of implants used in human bodies; in these applications, excellent corrosion resistance and anticoagulant properties are necessary.

系统研究了用聚己内酯（PCL）薄膜改性的316L不锈钢（316L SS）的表面和蛋白质吸附特性。PCL薄膜的润湿性与裸露的316L SS相当，因为PCL薄膜粗糙的表面形态抵消了它们的疏水性。用PCL薄膜进行表面改性显著提高了316L SS的耐腐蚀性，因为PCL本质上是绝缘的。在二辛可宁酸蛋白质测定中，PCL薄膜涂层有效地减少了316L SS表面上粘附的牛血清白蛋白（BSA）的量。PCL具有生物可降解性和生物相容性，这表明对用于人体的植入物进行表面改性具有潜力；在这些应用中，优异的耐腐蚀性和抗凝血性能是必需的。