Reyes-Ortega Felisa, Delgado Ángel V, Schneider Elena K, Checa Fernández B L, Iglesias G R
Department of Applied Physics, University of Granada, Av. Fuentenueva s/n, 18071 Granada, Spain.
Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences; Monash University, Parkville, Victoria 3052, Australia.
Polymers (Basel). 2017 Dec 22;10(1):10. doi: 10.3390/polym10010010.
Magnetic nanoparticles (MNPs) have been widely used to increase the efficacy of chemotherapeutics, largely through passive accumulation provided by the enhanced permeability and retention effect. Their incorporation into biopolymer coatings enables the preparation of magnetic field-responsive, biocompatible nanoparticles that are well dispersed in aqueous media. Here we describe a synthetic route to prepare functionalized, stable magnetite nanoparticles (MNPs) coated with a temperature-responsive polymer, by means of the hydrothermal method combined with an oil/water (o/w) emulsion process. The effects of both pH and temperature on the electrophoretic mobility and surface charge of these MNPs are investigated. The magnetite/polymer composition of these systems is detected by Fourier Transform Infrared Spectroscopy (FTIR) and quantified by thermogravimetric analysis. The therapeutic possibilities of the designed nanostructures as effective heating agents for magnetic hyperthermia are demonstrated, and specific absorption rates as high as 150 W/g, with 20 mT magnetic field and 205 kHz frequency, are obtained. This magnetic heating response could provide a promising nanoparticle system for combined diagnostics and cancer therapy.
磁性纳米颗粒（MNPs）已被广泛用于提高化疗药物的疗效，主要是通过增强渗透和滞留效应实现的被动积累。将它们掺入生物聚合物涂层中，可以制备出在水性介质中分散良好的磁场响应性、生物相容性纳米颗粒。在此，我们描述了一种合成路线，通过水热法结合油/水（o/w）乳液工艺，制备涂覆有温度响应聚合物的功能化、稳定的磁铁矿纳米颗粒（MNPs）。研究了pH值和温度对这些MNPs的电泳迁移率和表面电荷的影响。通过傅里叶变换红外光谱（FTIR）检测这些体系的磁铁矿/聚合物组成，并通过热重分析进行定量。展示了所设计的纳米结构作为磁热疗有效加热剂的治疗潜力，在20 mT磁场和205 kHz频率下，获得了高达150 W/g的比吸收率。这种磁热响应可为联合诊断和癌症治疗提供一个有前景的纳米颗粒系统。
