Department of Ecology and Evolutionary Biology, Yale University, PO Box 208106, New Haven, CT, 06520-8106, USA.
J Mol Evol. 2020 Jan;88(1):3-11. doi: 10.1007/s00239-019-09893-5. Epub 2019 Apr 9.
This paper surveys some of the important insights that molecular evolution has contributed to evolutionary medicine; they include phage therapy, cancer biology, helminth manipulation of the host immune system, quality control of gametes, and pathogen outbreaks. Molecular evolution has helped to revolutionize our understanding of cancer, of autoimmune disease, and of the origin, spread, and pathogenesis of emerging diseases, where it has suggested new therapies, illuminated mechanisms, and revealed historical processes: all have practical therapeutic implications. While much has been accomplished, much remains to be done.
本文调查了分子进化对进化医学的一些重要贡献；它们包括噬菌体治疗、癌症生物学、寄生虫对宿主免疫系统的操纵、配子的质量控制和病原体爆发。分子进化有助于彻底改变我们对癌症、自身免疫性疾病以及新发疾病的起源、传播和发病机制的理解，它为新疗法提供了启示，阐明了机制，并揭示了历史进程：所有这些都具有实际的治疗意义。虽然已经取得了很大的成就，但仍有许多工作要做。
