Office of Intramural Research, Center for Information Technology, National Institutes of Health, Bethesda, MD, USA.
Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
J Dent Res. 2021 Dec;100(13):1510-1519. doi: 10.1177/00220345211014432. Epub 2021 May 25.
Saliva has become an attractive body fluid for on-site, remote, and real-time monitoring of oral and systemic health. At the same time, the scientific community needs a saliva-centered information platform that keeps pace with the rapid accumulation of new data and knowledge by annotating, refining, and updating the salivary proteome catalog. We developed the Human Salivary Proteome (HSP) Wiki as a public data platform for researching and retrieving custom-curated data and knowledge on the saliva proteome. The HSP Wiki is dynamically compiled and updated based on published saliva proteome studies and up-to-date protein reference records. It integrates a wide range of available information by funneling in data from established external protein, genome, transcriptome, and glycome databases. In addition, the HSP Wiki incorporates data from human disease-related studies. Users can explore the proteome of saliva simply by browsing the database, querying the available data, performing comparisons of data sets, and annotating existing protein entries using a simple, intuitive interface. The annotation process includes both user feedback and curator committee review to ensure the quality and validity of each entry. Here, we present the first overview of features and functions the HSP Wiki offers. As a saliva proteome-centric, publicly accessible database, the HSP Wiki will advance the knowledge of saliva composition and function in health and disease for users across a wide range of disciplines. As a community-based data- and knowledgebase, the HSP Wiki will serve as a worldwide platform to exchange salivary proteome information, inspire novel research ideas, and foster cross-discipline collaborations. The HSP Wiki will pave the way for harnessing the full potential of the salivary proteome for diagnosis, risk prediction, therapy of oral and systemic diseases, and preparedness for emerging infectious diseases.Database URL: https://salivaryproteome.nidcr.nih.gov/.
唾液已成为现场、远程和实时监测口腔和全身健康的有吸引力的体液。与此同时，科学界需要一个以唾液为中心的信息平台，通过注释、精炼和更新唾液蛋白质组目录来跟上新数据和知识的快速积累。我们开发了人类唾液蛋白质组（HSP）维基，作为一个研究和检索唾液蛋白质组定制数据和知识的公共数据平台。HSP 维基是根据已发表的唾液蛋白质组研究和最新的蛋白质参考记录动态编译和更新的。它通过从已建立的外部蛋白质、基因组、转录组和糖组数据库中导入数据，整合了广泛的可用信息。此外，HSP 维基还纳入了与人类疾病相关研究的数据。用户只需浏览数据库、查询可用数据、对数据集进行比较以及使用简单直观的界面注释现有蛋白质条目，即可轻松探索唾液中的蛋白质组。注释过程包括用户反馈和管理员委员会审查，以确保每个条目都具有高质量和有效性。在这里，我们首次概述了 HSP 维基提供的功能和特点。作为一个以唾液蛋白质组为中心的、可公开访问的数据库，HSP 维基将为广泛学科的用户提供有关唾液组成和功能在健康和疾病中的最新知识。作为一个基于社区的数据知识库，HSP 维基将作为一个全球性平台，用于交流唾液蛋白质组信息、激发新的研究思路并促进跨学科合作。HSP 维基将为充分利用唾液蛋白质组用于诊断、风险预测、口腔和全身疾病的治疗以及新兴传染病的准备铺平道路。数据库 URL：https://salivaryproteome.nidcr.nih.gov/。
