Department of Hematology and Immunohematology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Bahir Dar District Blood Bank, Bahir Dar, Ethiopia.
PLoS One. 2019 Apr 11;14(4):e0214755. doi: 10.1371/journal.pone.0214755. eCollection 2019.
Blood transfusion is an effective treatment for saving millions of lives even though transfusion- transmissible infections are the major problem. Therefore, the aim of this study was to assess the sero-prevalence and trend of transfusion-transmissible infections among blood donors.
A retrospective study was conducted form July 2014 to June 2018 at Bahir Dar district blood bank. Descriptive statistics was presented using percentages, medians and interquartile ranges. Logistic regression was used to explore risk factors associated with each transfusion transmissible infections.
From a total of 35,435 blood donors 2130 (6.0%) of them had serological evidence for at least one infection and 50 (0.14%) of them were confirmed as having multiple infections. The overall sero-prevalence of HBV, HCV, HIV and syphilis was 230 (6.0%) with 3.9%, 0.6%, 0.5% and 1.2% respectively. From those who had co-infection majority of them 22 (44.0%) were attributed to HBV-Syphilis co-infection and 1 (2.0%) study participant was co-infected with HBV-HIV- Syphilis infection. There was an increment in the overall prevalence of transfusion-transmissible infection;183 in 2014/2015 to 624 in 2017/2018. The sero-prevalence of HBV show a significant increment tend with respect to year of donation. On the other hand HCV and HIV sero-prevalence show an increasing trend from 2014 and decrease in 2018. The sero-prevalence of syphilis was 67 (1.3%) in 2015 and duplicate in 2016, 138 (1.5) but subsequently decrease to 110 (1.1%) in 2017 and in 2018 it was 114 (1.0%).
His finding showed growing evidence in the burden of transfusion-transmissible infection in blood donors despite which requires advanced and vigilance screening of donated blood prior to transfusion. More over there should be strategies for monitoring the implementation of post donation counseling for recruitment and retention of safe regular donors.
输血是挽救数百万人生命的有效治疗方法，尽管输血传播感染是主要问题。因此，本研究旨在评估献血者中输血传播感染的血清流行率和趋势。
本回顾性研究于 2014 年 7 月至 2018 年 6 月在巴赫达尔区血库进行。采用百分比、中位数和四分位间距表示描述性统计数据。采用逻辑回归分析与每种输血传播感染相关的危险因素。
在 35435 名献血者中，有 2130 名（6.0%）至少有一种感染的血清学证据，50 名（0.14%）被确认为多重感染。HBV、HCV、HIV 和梅毒的总血清流行率分别为 230（6.0%）、3.9%、0.6%、0.5%和 1.2%。在合并感染的人群中，大多数（44.0%）为 HBV-梅毒合并感染，1 名（2.0%）研究参与者合并感染 HBV-HIV-梅毒。总体输血传播感染的患病率呈上升趋势，2014/2015 年为 183 例，2017/2018 年为 624 例。HBV 的血清流行率呈显著递增趋势，与献血年份有关。另一方面，HCV 和 HIV 的血清流行率呈上升趋势，从 2014 年开始下降，2018 年又有所上升。梅毒的血清流行率在 2015 年为 67（1.3%），2016 年为 138（1.5%），随后在 2017 年下降至 110（1.1%），2018 年为 114（1.0%）。
尽管如此，尽管在献血前对捐献的血液进行了先进和警惕的筛查，但他的发现显示出输血传播感染的负担不断增加。此外，还应制定监测和实施献血后咨询的策略，以招募和保留安全的定期献血者。
