Hanif Aamir, Farooq Rabia, Rehman Muneeb U, Khan Rehan, Majid Sabhiya, Ganaie Majid Ahmad
City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong Special Administrative Region.
Department of Biochemistry, Govt Medical College (GMC) Srinagar, J&K 190010, India.
Saudi Pharm J. 2019 Mar;27(3):312-319. doi: 10.1016/j.jsps.2018.11.013. Epub 2018 Nov 24.
Nanobiosensors based on aptamer are extensively being studied as potent analytical tools in clinical analysis. These biosensors provide high sensitivity, fast response, specificity and desired portability in addition to simplicity and decreased cost compared to conventional methods. The purpose of this manuscript is to provide readers with an overview of current advances about electrochemical, electrochemiluminescent and photoelectrochemical aptasensors from the sea of available literature. These are mainly used for determination of protein-based biomarkers, especially for cancer diagnosis. Here in we have given special emphasis on nanosize-based aptasensors which have been reported to show considerable improvement in the analytical performance.
基于适配体的纳米生物传感器作为临床分析中强大的分析工具正在被广泛研究。与传统方法相比，这些生物传感器除了具有简单性和成本降低的优点外，还具有高灵敏度、快速响应、特异性和所需的便携性。本手稿的目的是从大量现有文献中为读者提供有关电化学、电化学发光和光电化学适配体传感器的当前进展概述。这些主要用于基于蛋白质的生物标志物的测定，特别是用于癌症诊断。在此，我们特别强调了基于纳米尺寸的适配体传感器，据报道这些传感器在分析性能上有显著提高。
