National Center for High Technology (CeNAT), National Laboratory of Nanotechnology (LANOTEC), San José 1174-1200, Costa Rica.
Physical Chemistry Laboratory, Faculty of Pharmacy, University of Costa Rica, San José 11501-2060, Costa Rica.
Sensors (Basel). 2020 Dec 4;20(23):6926. doi: 10.3390/s20236926.
Biosensors are measurement devices that can sense several biomolecules, and are widely used for the detection of relevant clinical pathogens such as bacteria and viruses, showing outstanding results. Because of the latent existing risk of facing another pandemic like the one we are living through due to COVID-19, researchers are constantly looking forward to developing new technologies for diagnosis and treatment of infections caused by different bacteria and viruses. Regarding that, nanotechnology has improved biosensors' design and performance through the development of materials and nanoparticles that enhance their affinity, selectivity, and efficacy in detecting these pathogens, such as employing nanoparticles, graphene quantum dots, and electrospun nanofibers. Therefore, this work aims to present a comprehensive review that exposes how biosensors work in terms of bacterial and viral detection, and the nanotechnological features that are contributing to achieving a faster yet still efficient COVID-19 diagnosis at the point-of-care.
生物传感器是能够感知多种生物分子的测量设备,广泛用于检测相关的临床病原体,如细菌和病毒,取得了突出的效果。由于 COVID-19 导致的另一场大流行的潜在风险仍然存在,研究人员一直在期待开发新的技术,用于诊断和治疗由不同细菌和病毒引起的感染。在这方面,纳米技术通过开发增强这些病原体的亲和力、选择性和检测效果的材料和纳米粒子,改进了生物传感器的设计和性能,例如使用纳米粒子、石墨烯量子点和静电纺纳米纤维。因此,这项工作旨在进行全面的综述,介绍生物传感器在细菌和病毒检测方面的工作原理,以及有助于在即时护理点实现更快但仍然有效的 COVID-19 诊断的纳米技术特点。