Almetwazi Mansour, Alwhaibi Monira, Balkhi Bander, Almohaini Hissah, Alturki Haya, Alhawassi Tariq, Ata Sondus, AlQahtani Nasser, Mahmoud Mansour, Alshammari Thamir
Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Medication Safety Research Chair, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Saudi Pharm J. 2019 Mar;27(3):384-388. doi: 10.1016/j.jsps.2018.12.007. Epub 2018 Dec 26.
To identify factors associated with glycemic control in type 2 diabetes mellitus patients in tertiary academic hospital.
This was a retrospective cross-sectional study of adults with type 2 diabetes mellitus. Data were extracted from the electronic health record (EHR) database for the period from 1st of January to 31st of December 2016. Participants were considered to have a glucose control if the HbA1c level was less than 7% [53 mmol/L]. Descriptive analysis and multivariable logistic regression model were performed to assess the factors associated with glycemic control.
A total of 728 patients were included in the study for which (65%) were female, and about 60% of the sample size was between 45 and 60 years old. Multivariate logistic regression model showed participants older than the age of 65 were less likely to have controlled diabetes compared to the younger participants (OR: 0.53 [CI: 0.30-0.93]). Moreover, those who had hypertension (OR: 0.61 [CI: 0.43-0.86]) and dyslipidemia (OR: 0.53 [CI: 0.38-0.74]) were less likely to have controlled diabetes, while those with asthma (OR: 2.06 [CI: 1.16-3.68]) were more likely to have controlled diabetes. The model also showed that vitamin D deficiency was not associated with glycemic control in type 2 diabetes patients (OR 0.80 [95% CI 0.58-1.12]).
These findings highlighted the need for appropriate management in older adult patients to prevent the complication of type 2 diabetes. Furthermore, attention should be exercised for patients with factors associated with poor glycemic control such as hypertension and dyslipidemia.
确定三级学术医院中2型糖尿病患者血糖控制的相关因素。
这是一项针对成年2型糖尿病患者的回顾性横断面研究。数据从2016年1月1日至12月31日期间的电子健康记录(EHR)数据库中提取。如果糖化血红蛋白(HbA1c)水平低于7%[53 mmol/L],则参与者被认为血糖得到控制。进行描述性分析和多变量逻辑回归模型以评估与血糖控制相关的因素。
共有728名患者纳入研究,其中65%为女性,约60%的样本年龄在45至60岁之间。多变量逻辑回归模型显示,与年轻参与者相比,65岁以上的参与者糖尿病得到控制的可能性较小(比值比:0.53[置信区间:0.30 - 0.93])。此外,患有高血压(比值比:0.61[置信区间:0.43 - 0.86])和血脂异常(比值比:0.53[置信区间:0.38 - 0.74])的患者糖尿病得到控制的可能性较小,而患有哮喘的患者(比值比:2.06[置信区间:1.16 - 3.68])糖尿病得到控制的可能性较大。该模型还表明,维生素D缺乏与2型糖尿病患者的血糖控制无关(比值比0.80[95%置信区间0.58 - 1.12])。
这些发现凸显了对老年患者进行适当管理以预防2型糖尿病并发症的必要性。此外,对于伴有血糖控制不佳相关因素(如高血压和血脂异常)的患者应予以关注。