Majewski Sara, Bhattacharya Tanya, Asztalos Manuela, Bohaty Benjamin, Durham Katherine C, West Dennis P, Hebert Adelaide A, Paller Amy S
Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Department of Dermatology, The UTHealth McGovern Medical School-Houston, Houston, Texas.
Pediatr Dermatol. 2019 Jul;36(4):442-447. doi: 10.1111/pde.13842. Epub 2019 Apr 15.
A cleansing body wash containing diluted sodium hypochlorite (0.006% NaOCl) was evaluated for management of moderate-to-severe Staphylococcus aureus-colonized, atopic dermatitis in children.
A 6-week, prospective, open-label study was conducted with 50 evaluable participants (ages 6 months to 17 years) who had moderate-to-severe atopic dermatitis with S aureus skin colonization documented by culture. Participants were instructed to continue using their current medications while using the study product, 0.006% NaOCl body wash, once daily to affected areas for 6 weeks. Primary outcome measures were Investigator's Global Assessment, Eczema Area and Severity Index, and Body Surface Area scores. Secondary outcome measures were the Visual Analog Scale for pruritus, Family Dermatology Life Quality Index, and Patient Satisfaction Questionnaire for Problem Areas. A subject daily diary and a six-item subject questionnaire that provided information on preferences for bleach bath vs body wash were secondary outcome measures.
Daily use of the 0.006% NaOCl body wash led to improvement for all outcome measures comparing baseline to 2-week and to 6-week evaluations. Of the 50 skin S aureus-positive subjects, 32/50 (64%) were still positive at 2 weeks. A 36.5% decrease in subject's daily record of topical corticosteroid application at end of study compared to baseline was found. Participant surveys indicated preferences for the body wash over bleach baths.
Sodium hypochlorite (NaOCl) body wash improved all outcome measures for moderate-to-severe S aureus-colonized AD in infants, children, and adolescents. The limited reduction in S aureus further suggests that sodium hypochlorite has ameliorative effects other than antimicrobial actions.
评估一款含有稀释次氯酸钠（0.006% NaOCl）的沐浴露对儿童中重度金黄色葡萄球菌定植的特应性皮炎的治疗效果。
对50名可评估参与者（年龄6个月至17岁）进行了一项为期6周的前瞻性开放标签研究，这些参与者患有中重度特应性皮炎，且经培养证实有金黄色葡萄球菌皮肤定植。参与者被指示在使用研究产品（0.006% NaOCl沐浴露）的同时继续使用他们当前的药物，每天一次涂抹于受影响区域，持续6周。主要结局指标为研究者整体评估、湿疹面积和严重程度指数以及体表面积评分。次要结局指标为瘙痒视觉模拟量表、家庭皮肤病生活质量指数以及问题区域患者满意度问卷。受试者每日日记和一份提供关于漂白浴与沐浴露偏好信息的六项受试者问卷为次要结局指标。
与基线相比，在2周和6周评估时，每日使用0.006% NaOCl沐浴露使所有结局指标均有改善。在50名皮肤金黄色葡萄球菌阳性受试者中，32/50（64%）在2周时仍为阳性。研究结束时，与基线相比，受试者局部应用皮质类固醇的每日记录减少了36.5%。参与者调查表明，与漂白浴相比，他们更喜欢这款沐浴露。
次氯酸钠（NaOCl）沐浴露改善了婴儿、儿童和青少年中重度金黄色葡萄球菌定植的特应性皮炎的所有结局指标。金黄色葡萄球菌数量的有限减少进一步表明，次氯酸钠除了具有抗菌作用外，还有改善作用。
