Hwang Hyo-Jeong, Liu Yanan, Kim Hyun-Sook, Lee Heeseung, Lim Yunsook, Park Hyunjin
ICAN Nutrition Education and Research, 20, Gukjegeumyung-ro 7-gil, Yeongdeungpo-gu, Seoul 07340, Republic of Korea.
Department of Food and Nutrition, Sookmyung Women's University, Seoul 04310, Republic of Korea.
Nutr Res Pract. 2019 Apr;13(2):105-114. doi: 10.4162/nrp.2019.13.2.105. Epub 2019 Feb 11.
BACKGROUND/OBJECTIVES: Several previous studies have investigated whether regular walnut consumption positively changes heart-health-related parameters. The aim of this study was to investigate the effects of daily walnut intake on metabolic syndrome (MetS) status and other metabolic parameters among subjects with MetS.
SUBJECTS/METHODS: This study was a two-arm, randomized, controlled crossover study with 16 weeks of each intervention (45 g of walnuts or iso-caloric white bread) with a 6 week washout period between interventions. Korean adults with MetS (n = 119) were randomly assigned to one of two sequences; 84 subjects completed the trial. At each clinic visit (at 0, 16, 22, and 38 weeks), MetS components, metabolic parameters including lipid profile, hemoglobin A1c (HbA1c), adiponectin, leptin, and apolipoprotein B, as well as anthropometric and bioimpedance data were obtained.
Daily walnut consumption for 16 weeks improved MetS status, resulting in 28.6%-52.8% reversion rates for individual MetS components and 51.2% of participants with MetS at baseline reverted to a normal status after the walnut intervention. Significant improvements after walnut intake, compared to control intervention, in high-density lipoprotein cholesterol (HDL-C) ( = 0.028), fasting glucose ( = 0.013), HbA1c ( = 0.021), and adiponectin ( = 0.019) were observed after adjustment for gender, age, body mass index, and sequence using a linear mixed model.
A dietary supplement of 45 g of walnuts for 16 weeks favorably changed MetS status by increasing the concentration of HDL-C and decreasing fasting glucose level. Furthermore, consuming walnuts on a daily basis changed HbA1c and circulating adiponectin levels among the subjects with MetS. This trial is registered at ClinicalTrials.gov as NCT03267901.
背景/目的：此前已有多项研究探讨了经常食用核桃是否会对心脏健康相关参数产生积极影响。本研究的目的是调查每日摄入核桃对代谢综合征（MetS）患者的MetS状态及其他代谢参数的影响。
受试者/方法：本研究为双臂、随机、对照交叉研究，每种干预为期16周（45克核桃或等热量白面包），干预之间有6周的洗脱期。患有MetS的韩国成年人（n = 119）被随机分配到两个序列之一；84名受试者完成了试验。在每次门诊就诊时（第0、16、22和38周），获取MetS组分、包括血脂谱、糖化血红蛋白（HbA1c）、脂联素、瘦素和载脂蛋白B在内的代谢参数，以及人体测量和生物阻抗数据。
每日食用核桃16周可改善MetS状态，导致各MetS组分的逆转率为28.6% - 52.8%，且基线时患有MetS 的参与者中有51.2%在核桃干预后恢复到正常状态。使用线性混合模型对性别、年龄、体重指数和序列进行调整后，观察到与对照干预相比，摄入核桃后高密度脂蛋白胆固醇（HDL-C)(P = 0.02８)、空腹血糖(P = ０.０１３)、HbA1c(P = 0.021)和脂联素(P = 0 .019)有显著改善。
连续１６周每日补充４５克核桃可通过提高HDL-C浓度和降低空腹血糖水平来改善MetS状态。此外，每日食用核桃可改变MetS患者的HbA１c和循环脂联素水平。本试验已在ClinicalTrials.gov上注册，注册号为NCT03267901。
