细胞毒性T细胞是宿主对流感肺炎反应的一部分的证据。
Evidence that cytotoxic T cells are part of the host's response to influenza pneumonia.
作者信息
Ennis F A, Wells M A, Butchko G M, Albrecht P
出版信息
J Exp Med. 1978 Nov 1;148(5):1241-50. doi: 10.1084/jem.148.5.1241.
Abstract
Cytotoxic T cells were detected in the cervical lymph nodes, lungs, spleen, and peripheral blood of mice with influenza. Lymphocytes decreased in the peripheral circulation and increased in the lung during the period of acute inflammation and pneumonia. Peak cytotoxic T-cell activity was present at the time of marked pulmonary infiltration, and it decreased with resolution of the pneumonia. The cytotoxic T cells in the lung were shown to be H-2 restricted and specific for the hemagglutinin of the infecting virus. The results indicate that hemagglutinin specific cytotoxic T cells are (a) induced during influenza infection; (b) they circulate in the blood; (c) they are present in greatest number; and (d) they have their peak cytotoxic effect when pneumonia is most marked. We interpret the results to indicate that specific cytotoxic T cells in the infected target organ are part of the immunological and pathological response to virus infection.
摘要
在感染流感的小鼠的颈部淋巴结、肺、脾脏和外周血中检测到细胞毒性T细胞。在急性炎症和肺炎期间，外周循环中的淋巴细胞减少，而肺中的淋巴细胞增加。细胞毒性T细胞活性在肺部明显浸润时达到峰值，并随着肺炎的消退而降低。肺中的细胞毒性T细胞显示为H-2限制性，且对感染病毒的血凝素具有特异性。结果表明，血凝素特异性细胞毒性T细胞：(a) 在流感感染期间被诱导；(b) 在血液中循环；(c) 数量最多；(d) 在肺炎最明显时具有最大的细胞毒性作用。我们将这些结果解释为表明感染的靶器官中的特异性细胞毒性T细胞是对病毒感染的免疫和病理反应的一部分。
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