Guber Josef, Pereni Ioana, Scholl Hendrik P N, Guber Ivo, Haynes Richard J
Eye Clinic, Cantonal Hospital St. Gallen, St. Gallen, Switzerland.
Department of Ophthalmology, University Hospital of Basel, Basel, Switzerland.
Ophthalmol Ther. 2019 Jun;8(2):297-303. doi: 10.1007/s40123-019-0185-7. Epub 2019 Apr 19.
The aim of this study was to assess the incidence of persistent postoperative cystoid macular edema (pCME) in patients undergoing pars plana vitrectomy with epiretinal membrane peel (ERM) only versus those with ERM peel combined with internal limiting membrane peel (ILM). Secondary endpoints of the study were to review both the central macular thickness (CMT) and visual acuity.
The patients were divided in two groups, one group in which only the ERM was peeled (n = 36 patients) and another group in which both the ERM and the ILM were removed (n = 62 patients). The results were analyzed retrospectively. Each patient received a complete ophthalmological examination, including best-corrected visual acuity (BCVA) using an ETDRS chart and spectral domain optical coherence tomography, at three time points: prior to surgery and 3 weeks and 3 months after surgery.
A total 98 eyes of 98 patients were included in this study. The mean follow-up time was 7.7 months. CMT decreased significantly after surgery in all patients, and none of these changes differed significantly between the two groups. The BCVA increased significantly after surgery across all patients, and there were no significant changes between the two treatment groups. Postoperative pCME occurred in eight patients in each group, representing 22.2% of the 36 patients in the ERM only group and 12.9% of the 62 patients in the ERM/ILM peel group. However, this difference was not statistically significant.
No difference was found between the two groups in terms of incidence of pCME. Both groups experienced had similar decrease in the CMT and improvement in the BCVA postoperatively.
本研究的目的是评估仅行玻璃体视网膜前膜剥除术（ERM）的患者与行ERM剥除联合内界膜剥除术（ILM）的患者术后持续性黄斑囊样水肿（pCME）的发生率。该研究的次要终点是评估中心黄斑厚度（CMT）和视力。
将患者分为两组，一组仅剥除ERM（n = 36例患者），另一组同时剥除ERM和ILM（n = 62例患者）。对结果进行回顾性分析。每位患者在三个时间点接受全面的眼科检查，包括使用ETDRS视力表测量最佳矫正视力（BCVA）以及进行频域光学相干断层扫描：手术前、手术后3周和3个月。
本研究共纳入98例患者的98只眼。平均随访时间为7.7个月。所有患者术后CMT均显著降低，两组之间的这些变化无显著差异。所有患者术后BCVA均显著提高，两个治疗组之间无显著变化。每组均有8例患者发生术后pCME，占仅剥除ERM组36例患者的22.2%，占ERM/ILM剥除组62例患者的12.9%。然而，这种差异无统计学意义。
两组在pCME发生率方面无差异。两组术后CMT均有相似程度的降低，BCVA均有相似程度的改善。
