Guo Yiqun, Bai Yu, Yang Chunxia, Gu Li
Department of Infectious Diseases and Clinical Microbiology, Beijing Chao-yang Hospital, Capital Medical University, Beijing, China.
Medicine (Baltimore). 2019 Apr;98(16):e15021. doi: 10.1097/MD.0000000000015021.
Chronic pulmonary aspergillosis (CPA) is a slowly progressing pulmonary fungal infectious disease caused by Aspergillus. Aspergillus IgG, IgM are now considered to be valuable biomarkers in CPA diagnosing.Our research attempts to evaluate the effectiveness of Aspergillus IgG, IgM in diagnosing CPA.In our study, CPA patients were younger than the patients who suffered other pulmonary disease. The most common underlying disease in CPA patients was pulmonary tuberculosis. And the most common clinical symptom was hemoptysis. The comparison among the groups indicated statistical significance with regard to Aspergillus IgG and IgM between the CPA and other pulmonary disease groups (P < .01). The Aspergillus-specific IgG and IgM in infectious group exhibited higher levels than those in colonization group (P < .01). The area under the receiver operating characteristic curve of Aspergillus IgG was 0.762 (95% confidence interval: 0.664-0.860) (P < .01).Aspergillus-specific IgG offers great diagnostic value with regard to CPA.
慢性肺曲霉病（CPA）是一种由曲霉菌引起的缓慢进展的肺部真菌感染性疾病。曲霉IgG、IgM现在被认为是CPA诊断中有价值的生物标志物。我们的研究旨在评估曲霉IgG、IgM在诊断CPA中的有效性。在我们的研究中，CPA患者比患有其他肺部疾病的患者更年轻。CPA患者最常见的基础疾病是肺结核。最常见的临床症状是咯血。组间比较表明，CPA组与其他肺部疾病组之间曲霉IgG和IgM具有统计学意义（P <.01）。感染组中的曲霉特异性IgG和IgM水平高于定植组（P <.01）。曲霉IgG的受试者工作特征曲线下面积为0.762（95%置信区间：0.664 - 0.860）（P <.01）。曲霉特异性IgG对CPA具有很大的诊断价值。
