ACS Nano. 2019 May 28;13(5):4869-4875. doi: 10.1021/acsnano.9b02816. Epub 2019 Apr 29.
Pathogenic oral biofilms are universal, chronic, and costly. Despite advances in understanding the mechanisms of biofilm formation and persistence, novel and effective treatment options remain scarce. Nanoparticle-mediated eradication of the biofilm matrix and resident bacteria holds great potential. In particular, nanoparticles that target specific microbial and biofilm features utilizing nontoxic materials are well-suited for clinical translation. However, much work remains to characterize the local and systemic effects of therapeutic agents that are topically applied to chronic biofilms, such as those that cause dental caries. In this Perspective, we summarize the pathogenesis of oral biofilms, describe current and future nanoparticle-mediated treatment approaches, and highlight outstanding questions that are paramount to answer for effectively targeting and treating oral biofilms.
致病口腔生物膜是普遍存在的、慢性的且代价高昂的。尽管人们对生物膜形成和持续存在的机制有了更多的了解，但新的有效治疗方法仍然很少。纳米颗粒介导的生物膜基质和常驻细菌的消除具有巨大的潜力。特别是利用无毒材料针对特定微生物和生物膜特征的靶向纳米颗粒非常适合临床转化。然而，仍有许多工作需要描述局部和全身效应的治疗药物，这些药物是局部应用于慢性生物膜，例如那些导致龋齿的药物。在这篇观点文章中，我们总结了口腔生物膜的发病机制，描述了当前和未来的纳米颗粒介导的治疗方法，并强调了为有效地靶向和治疗口腔生物膜而必须回答的突出问题。
