The Effects of Cinnamaldehyde (Cinnamon Derivatives) and Nystatin on and .

BACKGROUND

Candida species are the most common opportunistic fungal infections. Today, cinnamon plants have been considered for anti-Candida properties.

AIM

This study aimed to investigate the effectiveness of cinnamaldehyde extract (from cinnamon derivatives) on and species and comparison with nystatin.

MATERIAL AND METHODS

In this study, cinnamaldehyde and nystatin were used. The specimens included and . Minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) were measured for each one by the microdilution method. This experiment was repeated three times.

RESULTS

Cinnamaldehyde extract at a concentration of 62.5 μl/ml was able to prevent the growth of , at a concentration of 93.7 μl/ml, causing to disappear, at 48.8 μl/ml, to prevent the growth of , and in the concentration of 62.5 μl/ml, causes the loss of . In comparison, nystatin at 0.5 μg/ml concentration prevented the growth of , at concentrations of 1 μg/ml causing to be destroyed, at 4 μg/ml concentration to prevent the growth of , and at a concentration of 8 μg/ml causes the loss of . The results were the same every three times.

CONCLUSIONS

Although cinnamaldehyde extract had an effect on fungal growth in both and with a fatal effect; the effect on these two species was lower than nystatin.