Han Xue, Liu Kun, Sun Changsen
School of Optoelectronic Engineering and Instrumentation Science, Dalian University of Technology, Dalian 116024, China.
Materials (Basel). 2019 Apr 30;12(9):1411. doi: 10.3390/ma12091411.
Techniques based on plasmonic resonance can provide label-free, signal enhanced, and real-time sensing means for bioparticles and bioprocesses at the molecular level. With the development in nanofabrication and material science, plasmonics based on synthesized nanoparticles and manufactured nano-patterns in thin films have been prosperously explored. In this short review, resonance modes, materials, and hybrid functions by simultaneously using electrical conductivity for plasmonic biosensing techniques are exclusively reviewed for designs containing nanovoids in thin films. This type of plasmonic biosensors provide prominent potential to achieve integrated lab-on-a-chip which is capable of transporting and detecting minute of multiple bio-analytes with extremely high sensitivity, selectivity, multi-channel and dynamic monitoring for the next generation of point-of-care devices.
基于等离子体共振的技术能够为分子水平的生物颗粒和生物过程提供无标记、信号增强且实时的传感手段。随着纳米制造和材料科学的发展，基于合成纳米颗粒以及在薄膜中制造的纳米图案的等离子体技术得到了广泛探索。在这篇简短的综述中，专门针对含有纳米孔洞的薄膜设计，综述了用于等离子体生物传感技术的共振模式、材料以及同时利用电导率的混合功能。这类等离子体生物传感器为实现集成化芯片实验室提供了显著潜力，该芯片实验室能够以极高的灵敏度、选择性、多通道以及动态监测能力，传输和检测微量的多种生物分析物，以用于下一代即时检测设备。
