Department of Psychiatry, Weill Institute for Neuroscience, Kavli Institute for Fundamental Neuroscience, and Sloan-Swartz Center for Theoretical Neurobiology, University of California, San Francisco, 675 Nelson Rising Lane, San Francisco, CA 94143-0444, USA.
Department of Psychiatry, Weill Institute for Neuroscience, Kavli Institute for Fundamental Neuroscience, and Sloan-Swartz Center for Theoretical Neurobiology, University of California, San Francisco, 675 Nelson Rising Lane, San Francisco, CA 94143-0444, USA.
Neuron. 2019 Jun 19;102(6):1223-1234.e4. doi: 10.1016/j.neuron.2019.04.001. Epub 2019 Apr 30.
Inhibitory interneurons expressing vasoactive intestinal polypeptide (VIP) are known to disinhibit cortical neurons. However, it is unclear how disinhibition, occurring at the single-cell level, interacts with network-level patterns of activity to shape complex behaviors. To address this, we examined the role of prefrontal VIP interneurons in a widely studied mouse behavior: deciding whether to explore or avoid the open arms of an elevated plus maze. VIP interneuron activity increases in the open arms and disinhibits prefrontal responses to hippocampal inputs, which are known to transmit signals related to open arm avoidance. Indeed, inhibiting VIP interneurons disrupts network-level representations of the open arms and decreases open arm avoidance specifically when hippocampal-prefrontal theta synchrony is strong. Thus, VIP interneurons effectively gate the ability of hippocampal input to generate prefrontal representations, which drive avoidance behavior. This shows how VIP interneurons enable cortical circuits to integrate specific inputs into network-level representations that guide complex behaviors. VIDEO ABSTRACT.
表达血管活性肠肽 (VIP) 的抑制性中间神经元已知可解除皮质神经元的抑制。然而，尚不清楚在单细胞水平发生的去抑制作用如何与网络级别的活动模式相互作用，从而塑造复杂行为。为了解决这个问题，我们研究了前额叶 VIP 中间神经元在一种广泛研究的小鼠行为中的作用：决定是探索还是回避高架十字迷宫的开放臂。在开放臂中，VIP 中间神经元的活动增加，并解除了前额叶对海马传入的反应抑制，已知海马传入信号与开放臂回避有关。事实上，抑制 VIP 中间神经元会破坏开放臂的网络级表示，并且仅当海马-前额叶θ同步性较强时，会特异性地减少开放臂回避。因此，VIP 中间神经元有效地控制海马输入产生前额叶表示的能力，从而驱动回避行为。这表明 VIP 中间神经元如何使皮质回路将特定输入整合到指导复杂行为的网络级表示中。视频摘要。
